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03-23-2016, 08:31 PM   #1
Eridon2002
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Join Date: Jul 2014
Location: Saint Louis, Missouri

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Prunella Vulgaris

The common name for this plant is "self heal" It acts by inhibiting the activation of the NF-kB pathway of which NOD2 is a part of. NOD2 mutations are associated with Crohn's disease. There are a few theories on NOD2's role in CD but one is "NOD2 acts as a negative regulator following bacterial stimulation of the cell surface receptor toll-like receptor-2, and that the CD-associated mutations result in a loss of this “brake” on the immune response leading to elevated NFkB" Thought I would share this since I find it very interesting. I actually have some Prunella Vulgaris growing in my yard. I think I will make some tea with it and see how it goes...

"Nutraceutical efficacy in experimental animal
models of inflammatory bowel disease"
http://lib.dr.iastate.edu/cgi/viewco...35&context=etd

"Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a-/- mice"
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635162/

"Association of NOD2 with Crohn's disease"
http://emedicine.medscape.com/article/1790325-overview
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