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Crohn's Disease Forum » Books, Multimedia, Research & News » An oral drug used to treat Rheumatoid Arthritis found to help IBD.


03-23-2016, 11:19 PM   #1
wildbill_52280
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An oral drug used to treat Rheumatoid Arthritis found to help IBD.

A oral drug used to treat rheumatoid arthritis helps IBD.

http://www.healio.com/gastroenterolo...-crohns-trials
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03-24-2016, 07:49 AM   #2
xeridea
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I'm not knocking it, but 43% drug vs. 37% placebo doesn't make a strong case.

Pfizer's got more promising CD treatments in its pipeline than this, I'd be surprised if they'd trial this further for CD.
03-24-2016, 12:03 PM   #3
wildbill_52280
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I'm not knocking it, but 43% drug vs. 37% placebo doesn't make a strong case.

Pfizer's got more promising CD treatments in its pipeline than this, I'd be surprised if they'd trial this further for CD.
I agree, not a strong case.
03-24-2016, 12:15 PM   #4
my little penguin
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Not strong but for those who have two diseases wher the meds don't always match
Good to have options
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03-24-2016, 12:29 PM   #5
smt
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Not strong but for those who have two diseases wher the meds don't always match
Good to have options
"The researchers concluded that clinical response or remission occurred in greater proportions of the treatment groups, but the results were not statistically significant. " (Highlights mine; from the article)

I do not find ANY case if the results are not statistically significant.
03-25-2016, 07:21 AM   #6
xeridea
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Not strong but for those who have two diseases wher the meds don't always match
Good to have options
I don't disagree with your position MLP but if you look further at this drug, some of its side-effects include GI bleeding and liver failure. The European regulators had so much concern re it's side-effects I don't think they approved it, at least a couple years ago when I first heard about it.

With such slim advantage over placebo, someone would have to do a real hard sell to justify taking this for Crohn's.
03-28-2016, 01:37 AM   #7
Charlotte.
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Thank you for sharing, wildbill.

Diarrhea seems to be a common side effect as well, so even if inflammation might decrease, symptoms are still there, as an effect of the drug itself.

Why don't we just all take placebos? At least one in three seems to benefit! Sorry, just kidding. These high remission rates from placebos always surprise me. I think it would be more helpful to test if remission is sustainable with placebo or the tested drug though?
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Crohn's Disease: diagnosed 2014 (at 24), symptoms for 10 years now
Enteropathic Arthritis, Sacroliitis, Osteopenia

Stelara; Uceris; Lansoprazole; Domperidone.

Previously: Remicade, Humira, Simponi, Azathioprine, Methotrexate, Sulfasalazine, Entocort, Uceris, Prednisolone, TPN, EEN, different alternative treatments.
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