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Crohn's Disease Forum » Diet, Fitness, and Supplements » L-Glutamine may work best when combined with Arginine


05-19-2016, 10:36 AM   #1
InstantCoffee
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L-Glutamine may work best when combined with Arginine

Just stumbled on some info suggesting that glutamine works best or only works significantly when combined with arginine, been trying to dig up some more reliable info on it:

http://www.livestrong.com/article/50...e-l-glutamine/

A 2010 paper published in "Current Opinion in Clinical Nutrition and Metabolic Care" found that l-glutamine and l-arginine were able to work together to improve health and inflammation response; however, l-arginine reduced l-glutamine's antioxidant properties. Although there is a lack of research on the combined effects of l-arginine and l-glutamine, the preliminary data shows that combining the two may benefit those with intestinal inflammation.
http://www.ncbi.nlm.nih.gov/pubmed/19904200

http://jn.nutrition.org/content/138/12/2481.full

Combined Glutamine and Arginine Decrease Proinflammatory Cytokine Production by Biopsies from Crohn's Patients in Association with Changes in Nuclear Factor-κB and p38 Mitogen-Activated Protein Kinase Pathways13
So those that have tried glutamine and had poor response, try combining with arginine in the future.
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05-19-2016, 12:39 PM   #2
wildbill_52280
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how about just increasing protein intake in general? it will give you all these amino acids at once, it's way more natural. I believe taking arginine alone has negatively affected my IBD, it likely enhanced the production of molecules that feed pathogens in the gut. Just make sure you get alot of fiber, high protein and low fiber diets are linked to crohn's development.
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05-19-2016, 01:38 PM   #3
InstantCoffee
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how about just increasing protein intake in general? it will give you all these amino acids at once, it's way more natural. I believe taking arginine alone has negatively affected my IBD, it likely enhanced the production of molecules that feed pathogens in the gut. Just make sure you get alot of fiber, high protein and low fiber diets are linked to crohn's development.
Arginine alone may increase nitric oxide which can be oxidative and stress the gut. Glutamine is an anti-oxidant, the arginine will cancel out the anti-oxidant benefits of glutamine but in return you get better gut healing. Arginine as a whole however is anti-oxidant in nature.

https://examine.com/supplements/arginine/

The standard pre-workout dose for L-arginine is 3-6g.

To maintain elevated arginine levels throughout the day, arginine can be taken up to three times a day, with a combined dose total of 15-18g. Note: L-Citrulline supplementation is more effective at maintaining elevated arginine levels for long periods of time.

Taking more than 10g of arginine at once can result in gastrointestinal distress and diarrhea.
The problem with relying on dietary intake is the percent available in food will not be nearly as great as supplementing it, you'd have to eat a lot of meat to get the same amount of glutamine you can easily and cheaply get in a supplemental form, and many peoples' digestive systems simply arent' healthy enough to break down and absorb the amino acids from a food source if they're turning to supplements to help themselves heal.

Glutamine is also not freely available in food sources typically and needs to be synthesized in the body from glutamic acid.
05-19-2016, 03:03 PM   #4
D Bergy
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L-Glutamine is one supplement that makes a noticeable difference in myself. I will have to try the combination and see if it works better of worse.

Thanks for the info.

Dan
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Crohn's Disease Forum » Diet, Fitness, and Supplements » L-Glutamine may work best when combined with Arginine
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