Crohn's Disease Forum » Treatment » Stelara/Ustekinumab » What meds have failed before you starred stelara?


02-16-2017, 05:55 AM   #1
woops!
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What meds have failed before you starred stelara?

Getting ready for my first dose Friday. just curious as to what meds have failed for everyone? Mine are humira, methotrexate, remicade, Pentasa.
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02-16-2017, 08:16 AM   #2
ronroush7
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For me, Cimzia worked for a while and then it failed. The second time around, I had an allergic reaction to Remicade. I also had an allergic reaction to Flagyl. The same thing happened with Doxycycline. For me personally, Stelara never did anything for the Crohns Disease but everyone is different. Best to you.

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Diagnosed in 1990. On Humira, Imuran, Gabapentin, Colestipol, Synthroid, Lialda. Resection in April of 2010. Allergic to Remicade, Penicillin, Flagyl, Doxycycline. Thyroid issues and psoriasis and neuropathy and mild cerebral palsy. Mild arthritis in my lower back.
02-16-2017, 10:11 AM   #3
jonique
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Getting ready for my first dose Friday. just curious as to what meds have failed for everyone? Mine are humira, methotrexate, remicade, Pentasa.
I tried humira, simponi, remicade, cimzia, methotrexate, sulfasalazine. Started stelara in April 2016 and it has been the best so far.

Good luck!

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Dx:
Crohn's Disease
IBD associated Spondyloarthropathy
Migraines
Moderate Fatty Liver

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5-ASA (Salofalk)
Celebrex
Omeprazole


Previous meds:
Stelara, Cimzia, Simponi, Remade, Humira, Methotrexate, Entocort, Sulfasalazine

Surgery:
1. laparotomy 1986 - Dx Crohn's Disease
2. small bowel resection 1995
3. small bowel resection 2016
02-16-2017, 12:31 PM   #4
my little penguin
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Ronroush were you on the higher dose for Crohns 90 mg or the lower psoriasis dose 45 mg?

They have found in order to be effective for Crohns
Stelera needs to be at a much higher dose (double ) that of psoriasis patients
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02-16-2017, 01:48 PM   #5
ronroush7
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Ronroush were you on the higher dose for Crohns 90 mg or the lower psoriasis dose 45 mg?

They have found in order to be effective for Crohns
Stelera needs to be at a much higher dose (double ) that of psoriasis patients
I am not sure.
02-16-2017, 06:12 PM   #6
Maya142
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For me, Cimzia worked for a while and then it failed. The second time around, I had an allergic reaction to Remicade. I also had an allergic reaction to Flagyl. The same thing happened with Doxycycline. For me personally, Stelara never did anything for the Crohns Disease but everyone is different. Best to you.
The Crohn's dose for Stelara is also given more frequently - 8 weeks vs. 12 weeks. So if it was prescribed for you as a psoriasis patient, then you may want to try it again at the IBD dose with the IV loading dose.
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02-16-2017, 06:16 PM   #7
ronroush7
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I may ask my doctor. I don't know if I am not having much success with Humira or if I have c diff. I think they might have been giving me the psoriasis level because I am not sure if it was approved for Crohns yet.

04-23-2017, 05:44 PM   #8
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I have failed Remicade, Humira, Entyvio, and Cimzia. Failed many oral medications. 4 surgeries and will need another one. Start Stelara in May 2017.
04-23-2017, 05:47 PM   #9
ronroush7
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I have failed Remicade, Humira, Entyvio, and Cimzia. Failed many oral medications. 4 surgeries and will need another one. Start Stelara in May 2017.
I hope you have much luck with Stelara.
04-24-2017, 10:35 AM   #10
jazzygirl52
 
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Hi everyone. I started on the Biologics for Crohns /UC about 3 years ago with Humira. I had to drop that even though my stomach was awesome on it, I developed plaque psorasis.

Now I am on Remicade infusions but I have problems with it spiking my BP so we are stopping Remicade. I also take the Imuran.

Next drug is either going to be Stelara or Entyvio. Does anyone have a recommendation with positive results on either of these? Is there one that is more risky for other diseases?
04-24-2017, 12:56 PM   #11
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Hello Jazzygirl52. Everyone responds differently to meds....I doctor at Mayo in Rochester MN. I was on Entyvio for a few months. Talk to your doctor and ask for the stats on Entyvio for Crohns patients. I think (if I remember correctly) 1 person responds to the medication out of 4.??? Not great results, but it may just work great for you. Didn't work at all for me. I am currently on Cimzia right now. Taking 1 injection every 10 days along with Imuran. Its not working. I have been on Imuran for 12 years always along with other meds & Biologics. I will start Stelara next month and continue with Imuran.
04-24-2017, 07:05 PM   #12
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I tried humira, simponi, remicade, cimzia, methotrexate, sulfasalazine. Started stelara in April 2016 and it has been the best so far.

Good luck!
I was on Pentasa for years then after colon cancer, put on Humira... allergic reaction to it in year two so switched to Remicade...not as good as Humira on my digestion and it made my BP go sky high. Now choice of Entyvio or Stelara?
04-25-2017, 06:15 AM   #13
eleanor_rigby
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I was on Pentasa for years then after colon cancer, put on Humira... allergic reaction to it in year two so switched to Remicade...not as good as Humira on my digestion and it made my BP go sky high. Now choice of Entyvio or Stelara?
I think entyvio takes longer to work. I've read Entyvio is generally more effective for people that have disease in their colon. If I had the choice I'd choose stelara as I have disease in my ileum/small bowel.
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2nd Generation affected

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Emergency open bowel resection after perforation in 12/2011 (age 22) (wrongly diagnosed as burst appendix ). Three years remission following this unmonitored

Diagnosis:
Perforating small bowel Crohn's Disease 01/2016 (terminal ileum, duodenum)
Coeliac disease (age 26)

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Gluten-free diet
04-25-2017, 04:14 PM   #14
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I think entyvio takes longer to work. I've read Entyvio is generally more effective for people that have disease in their colon. If I had the choice I'd choose stelara as I have disease in my ileum/small bowel.
Just saw my GI and we discussed the two options of Entyvio and Stelara. He says patients have had very good luck with Entyvio...Stelara is newly prescribed for this issue in 2016 so a lot less is known. I would rather something that is specifically targeted for the GI tract vs have an impact on lots of other parts of my body.... have a few months to figure out.... Stelara is a syringe injection that I would administer... prefer Humira type pens but we will see. Any other peeps have thoughts?
04-25-2017, 06:10 PM   #15
woops!
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I've been taking my Stelara now for about 10 weeks. It did take a while to work, but so far the results have been good. My current problem is c-diff. I plan to talk to GI about some good probiotics. Thanks for all the responses.
12-07-2017, 03:05 PM   #16
ney
 
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Failed:
Remicade and Humira. No improvements whatsoever, even with pred, 6mp, ASA, etc..

Success:
Tysabri - 3 1/2 yrs asymptomatic, but tested positive for JVC virus
And
Entyvio - 3 yrs asymptomatic, flared up after c-section, no response to med after that.. darn hormones!

Now: Stelara, first treatment today. We'll see
12-07-2017, 03:15 PM   #17
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Hum it’s great but gave me plaque psoriasis , Remicade raise my blood pressure and wasn’t great about controlling my symptoms. Went for initial dose of stelara and got one of the serious side effects pretty soon after the infusion was almost done – my tongue and throat kind of swelled up, the sides of my head felt tight. Went immediately to the ER from the infusion and was treated with 65 mg of prednisone – went home five hours later and Feel better, next day went back to get my car got dizzy again and my throat started swelling up so back to ER
12-07-2017, 03:15 PM   #18
jazzygirl52
 
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Good luck and stay at infusion to make sure you are ok
12-07-2017, 03:19 PM   #19
ney
 
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I'm hooked up to the IV as we speak. It's been on for about 45 minutes. No side effects yet. I'm on 30mg pred and 6mp while we transitioned from Entyvio to Stelara. Not sure if the prednisone is preventing any allergic reaction.
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