Crohn's Disease Forum » Books, Multimedia, Research & News » Brain-Gut Interactions in Inflammatory Bowel Disease Bruno L. Bonaz


03-24-2017, 06:33 AM   #1
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Brain-Gut Interactions in Inflammatory Bowel Disease Bruno L. Bonaz

Psycho-neuro-endocrine-immune modulation through
the brain-gut axis likely has a key role in the pathogenesis
of inflammatory bowel disease (IBD). The brain-gut
axis involves interactions among the neural components,
including (1) the autonomic nervous system, (2)
the central nervous system, (3) the stress system (hypothalamic-pituitary-adrenal
axis), (4) the (gastrointestinal)
corticotropin-releasing factor system, and (5) the
intestinal response (including the intestinal barrier,
the luminal microbiota, and the intestinal immune
response). Animal models suggest that the cholinergic
anti-inflammatory pathway through an anti–tumor
necrosis factor effect of the efferent vagus nerve could
be a therapeutic target in IBD through a pharmacologic,
nutritional, or neurostimulation approach. In
addition, the psychophysiological vulnerability of patients
with IBD, secondary to the potential presence of
any mood disorders, distress, increased perceived
stress, or maladaptive coping strategies, underscores
the psychological needs of patients with IBD. Clinicians
need to address these issues with patients because
there is emerging evidence that stress or other
negative psychological attributes may have an effect
on the disease course. Future research may include
exploration of markers of brain-gut interactions, including
serum/salivary cortisol (as a marker of the
hypothalamic-pituitary-adrenal axis), heart rate variability
(as a marker of the sympathovagal balance), or
brain imaging studies. The widespread use and potential
impact of complementary and alternative medicine
and the positive response to placebo (in clinical
trials) is further evidence that exploring other psychointerventions
may be important therapeutic adjuncts
to the conventional therapeutic approach in IBD.
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Diagnosed Crohn's 2007. Pentasa and several other drugs. Began exercising and taking better care of body in 2008. Lost 45 pounds, gradually reduced junk food, alcohol and tobacco. Stopped meds 2009. Went Gluten free, lactose free. Finally tobacco and alcohol free in 2013. Biopsies and internal camera since then come back with 'no trace of disease'.

Last edited by Cat-a-Tonic; 03-24-2017 at 03:03 PM. Reason: Fixed title
04-02-2017, 08:03 AM   #2
rollinstone
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MDMA to tread Ibd perhaps in a clinical setting, it would be cool to see trials.
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-Are you looking for a new treatment option for your Crohn's disease? If so, I suggest you look into the ongoing clinical trial by Qu Biologics for their SSI treatment. Click here for more information or to help spread the word.
04-02-2017, 10:35 AM   #3
Bufford
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· Stoma
No doubt that retirement has been key for maintaining remission for my system. The stress that came with the daily struggles of maintaining a job while living with uncontrolled Crohn's for decades did its damage. The colostomy bag has served me well in my later years in recovering some of those lost years.
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