Crohn's Disease Forum » Books, Multimedia, Research & News » He microbiology of butyrate formation in the human colon. Pryde SE


03-25-2017, 03:15 AM   #1
ebarker2
 
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He microbiology of butyrate formation in the human colon. Pryde SE

Abstract
Butyrate arising from microbial fermentation is important for the energy metabolism and normal development of colonic epithelial cells and has a mainly protective role in relation to colonic disease. While certain dietary substrates such as resistant starch appear to be butyrogenic in the colon, it is not known to what extent these stimulate butyrate production directly, e.g. by promoting amylolytic species, or indirectly, e.g. through cross-feeding of fermentation products. Cultural and molecular studies indicate that the most numerous butyrate-producing bacteria found in human faeces are highly oxygen-sensitive anaerobes belonging to the Clostridial clusters IV and XIVa. These include many previously undescribed species related to Eubacterium, Roseburia, Faecalibacterium and Coprococcus whose distribution and metabolic characteristics are under investigation. A better understanding of the microbial ecology of colonic butyrate-producing bacteria will help to explain the influence of diet upon butyrate supply, and to suggest new approaches for optimising microbial activity in the large intestine.
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Diagnosed Crohn's 2007. Pentasa and several other drugs. Began exercising and taking better care of body in 2008. Lost 45 pounds, gradually reduced junk food, alcohol and tobacco. Stopped meds 2009. Went Gluten free, lactose free. Finally tobacco and alcohol free in 2013. Biopsies and internal camera since then come back with 'no trace of disease'.
03-25-2017, 11:37 PM   #2
Trysha
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Interesting abstract...thank you for posting
The ecological balance of the intestinal microflora is essential to health.
The use of antibiotics so necessary to many of us causes an unbalance which interferes further with health.probiotics well chosen help to restore the balance.,
which may take up to a year.
03-29-2017, 05:24 AM   #3
edwards142
 
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i never think of this so deeply....thanks for sharing your work
03-29-2017, 12:10 PM   #4
Trysha
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Thank you Edwards
As you have guessed I am a clinical microbiologist and this is a topic of great interest
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