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05-10-2017, 03:36 PM   #1
Ladybug12
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Join Date: Jul 2016
Mtx dosage

I am curious to know the dosage prescribed to kids takinget methotrexate. My daughter currently gets a 10mg shot once a week. She feels very tired the following day.
05-10-2017, 04:13 PM   #2
malorymug
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Join Date: May 2014
Location: DFW, Texas

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7.5 mg / week orally and he feels fatigued for 24 to 36 hour after.

__________________
Mom to: 15 year old boy
Crohn's in stomach, small intestine, large intestine, and perianal disease
Diagnosed April 2014, at age 13

Currently taking:
Remicade 10mg/kg every 6 wks
Methotrexate 7.5 mg/wk
Cipro
Augmentin
Miralax

previous meds:
6mp 50mg
Flagyl
Cipro
Prednisone 30 mg
05-10-2017, 04:15 PM   #3
Maya142
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My daughters have been on anything from 7.5 mg to 25 mg. 25 mg is usually considered the highest dose, though I have heard of rheumatologists occasionally going up to 30 mg.

10 mg is a fairly low dose. My older daughter is on 15 mg. She is also usually a bit tired and nauseous the day after the shot. She takes folic acid daily and Zofran the day after the shot.

Is your daughter on folic acid? If so, what dose is it? Some kids need more to prevent side effects. My kiddos started on 1 mg daily, but it wasn't enough, so we went up to 2 mg daily.

There is also Leucovorin which is folinic acid. Rheumatologists seem to use it more than GIs for some reason. It is considered a "rescue" drug for MTX - used a LOT with cancer patients who take much higher doses. It is usually given 12 or 24 hours the MTX shot and can help with side effects.

However, it's usually given with much higher doses of MTX, since it does impact efficacy a little bit. My girls were on it when they were on 25 mg of MTX per week.
__________________
Mom of M (20)
diagnosed with Crohn's Disease at 16
Juvenile Idiopathic Arthritis at 12
Juvenile Ankylosing Spondylitis at 16

Mom of S (23)
dx with JIA at 14
Ankylosing Spondylitis at 18
05-10-2017, 04:55 PM   #4
pdx
Senior Member
 
Join Date: Dec 2014
Location: Portland, Oregon

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My daughter takes 15mg orally each week.
__________________
Daughter E (15) dx with Crohn's 12/18/14 at age 12

Current treatment:

Remicade started 12/24/14 (currently on 9 mg/kg every 6 weeks)
Oral methotrexate restarted 12/2/16 (15 mg weekly)
vitamin D, folic acid, multivitamin, Prozac

Past Treatment
90% EN via NG tube 2/9/15 - 4/2/15
50% EN via NG tube 4/3/15 - 4/18/15
Supplemental EN via NG tube 5/7/15-6/19/15
Budesonide 3/3/15-6/30/15
Oral methotrexate 3/13/15 - 5/14/16 (15 mg weekly)
Topical clobetasol for Remicade-induced psoriasis
05-10-2017, 05:04 PM   #5
my little penguin
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Join Date: Apr 2012

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Ds has been anywhere from
7.5 mg orally to 17.5 mg orally
And 7.5 mg to 25 mg injection
He gets very sick with injectable
Very few side effects orally
Also needs to take folic acid 1 mg x2 day
__________________
DS - -Crohn's -Stelara -mtx-IVIG
05-10-2017, 05:10 PM   #6
Ladybug12
Senior Member
 
Join Date: Jul 2016
My daughters have been on anything from 7.5 mg to 25 mg. 25 mg is usually considered the highest dose, though I have heard of rheumatologists occasionally going up to 30 mg.

10 mg is a fairly low dose. My older daughter is on 15 mg. She is also usually a bit tired and nauseous the day after the shot. She takes folic acid daily and Zofran the day after the shot.

Is your daughter on folic acid? If so, what dose is it? Some kids need more to prevent side effects. My kiddos started on 1 mg daily, but it wasn't enough, so we went up to 2 mg daily.

There is also Leucovorin which is folinic acid. Rheumatologists seem to use it more than GIs for some reason. It is considered a "rescue" drug for MTX - used a LOT with cancer patients who take much higher doses. It is usually given 12 or 24 hours the MTX shot and can help with side effects.

However, it's usually given with much higher doses of MTX, since it does impact efficacy a little bit. My girls were on it when they were on 25 mg of MTX per week.
She is currently taking 1mg of folic everyday.
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