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05-15-2017, 05:04 AM   #1
Sophabulous
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Gene breakthrough

http://www.dailymail.co.uk/health/ar...hn-s-cure.html
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Diagnosed severe Crohn's of the Duodenum, Terminal Ilium and Cecum.

Currently taking Azathioprine 100mg, Esomeprazole 40mg, B12 Injections and various supplements. Azathioprine failing so awaiting next steps
05-15-2017, 10:34 AM   #2
Tuff
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Amazon sells it, but it's $169.95. That's pretty steep for my budget, but I'd like to try it.
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Inflammatory bowel disease may more than double the risk of a serious blood clot in the legs or lungs.
************************************************** ********************************************

Stelara, Warfarin, calcium, Vitamins B12, D.
Previously: 5-Asa, Cipro, Flagyl, Prednisone, Aza, Remicade.
Pulmonary Embolism, DVT's, osteopenia, Peripheral neuropathy.
05-15-2017, 11:48 AM   #3
my little penguin
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Abstract
BACKGROUND: The multidrug resistance MDR1 gene codes for a membrane transporter associated with inflammatory bowel disease. The polymorphism Ala893Ser/Thr (G2677T/A) previously showed significant association with Crohn's disease (CD) and the Ile1145Ile (C3435T) with ulcerative colitis (UC). We studied the association of both polymorphisms in an independent population to reveal the impact of the MDR1 gene on predisposition to inflammatory bowel disease.

METHODS: Case-control study with 321 CD and 330 UC white Spanish patients recruited from the same center, and 352 healthy ethnically matched controls.

RESULTS: A significant association of MDR1 C3435T with CD was observed (CC vs (CT + TT): P = 0.007; OR [95% CI] = 1.58 [1.12-2.23]). A CD susceptibility haplotype 2677T/C3435 was identified. No difference between UC patients as a whole and controls could be detected.

CONCLUSIONS: New evidence supports the role of the MDR1 gene on CD susceptibility. Therefore, considering our results and those from others, the MDR1 gene behaves as a common risk factor for both CD and UC. We discovered that the C3435 allele conferring susceptibility to CD is different from the described 3435T UC risk allele.

From
https://www.ncbi.nlm.nih.gov/m/pubmed/16374256/


Dated 2006
So it's been looked at for at least 12 years now
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DS - -Crohn's -Stelara
05-15-2017, 05:28 PM   #4
Tuff
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Big Pharma will never pursue it I'm betting. There's no money in it. They'd rather have us take their toxic waste that causes cancer at $5000 a pop.
05-15-2017, 05:35 PM   #5
Sophabulous
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From

https://www.ncbi.nlm.nih.gov/m/pubmed/16374256/





Dated 2006

So it's been looked at for at least 12 years now


That must have been the inception I think, it looks like this was a much bigger study with far more people. I really hope they can go somewhere with it!
05-15-2017, 05:45 PM   #6
Tuff
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I really hope so too. I think I will order some as well. I'm getting so depressed and despondent because everything I've tried just causes more problems for me.
05-15-2017, 05:46 PM   #7
Sophabulous
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I really hope so too. I think I will order some as well. I'm getting so depressed and despondent because everything I've tried just causes more problems for me.


I'm sorry, it's certainly not easy any of this never mind if nothing helps. Let's hope something new comes of this that can do us all good ❤️
05-16-2017, 10:41 AM   #8
Bufford
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I hope this one will work. So far none of the treatments work for me, some work for awhile, but for the vast majority the side effects are worse than the scourge.
05-16-2017, 02:57 PM   #9
ronroush7
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I hope so too, Bufford.
05-17-2017, 04:21 AM   #10
njprrogers
 
Join Date: Dec 2009
Location: Dublin, Ireland
It sounds interesting. The size of the study i.e. 90,000 people would give you some hope that there is some merit to it. I have ordered some of the MitoQ from New Zealand. It cost 70 to ship 30 capsules... effectively this stuff is a bio-available version of COQ10 or Ubiquinol from my googling.

I'm far from 100% convinced... if I had a penny for every mouse that has been cured of colitis, I'd have about 1.50 :-)
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Crohn's disease in rectum and Lower left side
Diagnosed in 1983
Taking Imuran (Azathioprine) 125mg
Asacolon (Mesalazine) 3200mg
Tried Remicade / Humira / Vedolizumab but no joy
05-17-2017, 05:08 PM   #11
eleanor_rigby
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if i had a penny for every mouse that has been cured of colitis, i'd have about 1.50 :-)
lol
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