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Crohn's Disease Forum » Treatment » Entyvio/Vedolizumab » Use of Entyvio and TNF A blocker too

07-25-2017, 06:57 PM   #1
Roxymusic's Avatar
Join Date: Dec 2011
Location: Bloomington, Indiana

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Use of Entyvio and TNF A blocker too

Have any of you used Entyvio along with a biological such as remicade, Humira or cimzia? There have not been any trials, according to my gastro, and only some anecdotal evidence that a combination can work even better. Clearly, if it did, insurance would be a issue.

Both of them would not have been prescribed for crohns, but better crohns relief may have occurred.
DX Crohn's 1971
Crohn's Surgeries 1971, 1974, 1984x2, 1993, 2007,2016
11 Kidney Stones from 1996 due to resections
All the standard drugs/advice from the 70's 80's 90s
Now: Lyrica & Cymbalta (Neuropathy)
Fish Oil, B12 injection monthly
Dec 21 2011 started Remicade
February 2012 off of Pentase!
Nov 2014 Back on Imuran
Jan 2015 off Remicade
Mar 2015 on Humira
June 2016 on cimzia
Dx short Bowel July 2017
07-25-2017, 08:37 PM   #2
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ronroush7's Avatar
Join Date: Oct 2013
Location: vienna, Virginia

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I asked my doctor's office anout using both entyvio and Humira and they said no

Diagnosed in 1990. On Humira, Imuran, Gabapentin, Colestipol, Synthroid, Lialda. Resection in April of 2010. Allergic to Remicade, Penicillin, Flagyl, Doxycycline. Thyroid issues and psoriasis and neuropathy and mild cerebral palsy. Mild arthritis in my lower back.
07-26-2017, 05:42 PM   #3
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Maya142's Avatar
My daughter is on a combination of two biologics. She was on Entyvio + a biologic for her Ankylosing Spondylitis (not an anti-TNF).

Within two doses of Entyvio, she got drug-induced Lupus. Her GI had never seen drug-induced Lupus with Entyvio before and especially not that quickly, so she does wonder about it being the combination of biologics and not just Entyvio.

Now she is on an anti-TNF and IL-17. The anti-TNF is for her Crohn's, the IL-17 inhibitor is for her arthritis. So far, her Crohn's is definitely getting better, but her AS remains a mess.
Mom of M (20)
diagnosed with Crohn's Disease at 16
Juvenile Idiopathic Arthritis at 12
Juvenile Ankylosing Spondylitis at 16

Mom of S (23)
dx with JIA at 14
Ankylosing Spondylitis at 18
07-26-2017, 05:43 PM   #4
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Maya142's Avatar
I wanted to add - her GI and rheumatologist only agreed to do this because she has severe Ankylosing Spondylitis and we had already tried anti-TNFs by themselves (Remicade, Humira, Simponi) for the AS and Crohn's. The Crohn's responded, but the AS didn't which is why we moved on to other biologics.

They were very hesitant to put her on two biologics but we had tried everything else to avoid it (MTX, Imuran, Imuran with Allopurinol, Entocort, Sulfasalazine etc) and nothing worked.
07-26-2017, 06:25 PM   #5
my little penguin
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Join Date: Apr 2012

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Two biologics are not recommended for the same disease
If one pathway is how the disease works in an individual then only one biologic is needed
If it's a different pathway
Then you need a different type of biologic
Not two
DS - -Crohn's -Stelara -mtx-IVIG
10-29-2017, 04:58 PM   #6
Lady Organic
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I came across this ongoing study a while ago: Triple combo therapy phase 4:
''UC-like Crohn's'' since 2001:
on: 25mg 6-MP (purinethol)+ B12 shots
minor hands/wrists chronic arthritis since 01/2013

Diet: ''IBD-AID'' : organic food only
suppl Curcuminoid extract, Inulin,psyllium, apple pectin, Vitamin D

past meds:
pred 50mg, 5-ASA, cortifoam, Imuran (failed) Purinethol (success) methotrexate (failed CD and arthritis).
10-30-2017, 03:34 PM   #7
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Join Date: May 2017

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So far no guideline recommends the use of two biologics.
Maybe new studies or trial will help understand better if that could help.

Crohn's Disease Forum » Treatment » Entyvio/Vedolizumab » Use of Entyvio and TNF A blocker too
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