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Crohn's Disease Forum » Treatment » Imuran/Azathioprine/6-MP » Pregnancy and azathioprine


09-07-2017, 03:45 PM   #1
hayley00uk
 
Join Date: Feb 2013
Location: uk
Pregnancy and azathioprine

Im considering the possibility of having a child in the future I recently spoke to a doctor about it as im on azathioprine and ive been given conflicting advice the dr said its dangerous to stay on the tabs whilst pregnant while others say its ok because if i come off my meds there is a higher risk to the baby . Is there anyone on here that has been pregnant whilst taking aza and what did they experience??
09-09-2017, 04:33 PM   #2
Sophabulous
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Not personally, but someone I know came off biologics and onto azathioprine some years ago. She's had 2 healthy babies since whilst continuing treatment, and I believe both were breastfed.

I think it's a case of weighing up the risks of taking it, against the risks of a flare up during pregnancy and the damage that could do. I don't have the answer but I wish you all the best x
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Diagnosed severe Crohn's of the Duodenum, Terminal Ilium and Cecum.

Currently taking Azathioprine 100mg, Esomeprazole 40mg, B12 Injections and various supplements. Azathioprine failing so awaiting next steps
09-09-2017, 10:08 PM   #3
BlindLogic
 
Join Date: Feb 2014
Location: Springfield, Missouri
You can find a lot of good information relevant to your question by doing a keyword search. Press the search button on the banner at the top of the page and type in the keywords pregnancy and azathioprine (or imuran). Best of luck.
09-10-2017, 02:25 AM   #4
DustyKat
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I have no personal experience with this but have a look through this forum;

http://www.crohnsforum.com/forumdisplay.php?f=45

Also this publication covers all aspects of pregnancy and IBD, including meds;

There have been, in recent years, significant changes in the risk assessment for use of the immunomodulatory drugs azathioprine and 6-mercaptopurine (6-MP).

While it was believed only a few years ago that use of these drugs before a planned pregnancy or during the pregnancy itself was associated with a relatively high risk of side effects (miscarriage, premature birth, birth defects), current data and the increased use of azathioprine and 6-MP in other disorders (e.g. organ transplantation, rheumatoid arthritis) have shown that use of these drugs before or during pregnancy is not associated with an increased risk of complications during pregnancy or with birth defects in the child.

There have also been a number of case reports that suggest that patients with inflammatory bowel diseases do not experience an increased risk due to use of azathioprine or 6-MP. Naturally, there can be no 100% guarantee that a given drug will not adversely affect the course of pregnancy. A careful review of the literature also reveals case reports which show a slightly increased rate of pregnancy complications and miscarriages in association with the use of azathioprine or 6-MP. Upon closer examination, however, it becomes rapidly clear that, because of the small number of cases, no statistical conclusions can be made; in addition, other factors, such as an increased disease activity, may be responsible for the negative effects in these patients.

Thus, a consensus has formed in Europe and the United States that azathioprine and 6-MP can be used during pregnancy if medically necessary and, in fact, should be used if other measures fail to control inflammatory activity. The decision on whether azathioprine should be stopped in women planning a pregnancy or whether con-ception should be planned during ongoing azathioprine therapy requires careful consideration of the advantages and disadvantages and comprehensive counseling of the parents. This decision requires a high degree of responsibility and should include a joint interview between the parents, the treating gynecologist and/or family physician, as well as a gastroenterologist with the corresponding experience. There is no indication for pregnancy termination in women who become pregnant while being treated with azathioprine or 6-MP.

Also controversial is the use of azathioprine or 6-MP by the male partner in couples planning a pregnancy. Here, too, extensive experience from transplantation medicine and in patients with rheumatic disorders and inflammatory bowel diseases who were treated with azathioprine or 6-MP prior to or during the period of conception does not reveal any increased risk for pregnancy complications or birth defects. As with women, however, there are also individual case reports in the scientific literature that suggest possible negative effects on pregnancy secondary to azathioprine or 6-MP. Here, too, data is based on a very small number of cases, which precludes statistical evaluation. European and American pharmaceutical regulatory agencies do not currently recommend that males being treated with azathioprine or 6-MP should discontinue therapy prior to a planned conception. Patients desiring maximum safety, however, can be advised to discontinue azathioprine three months prior to a planned conception. In the intervening period, males will produce sperm whose genetic material is not damaged by azathioprine.

Over the past years, we have followed a large number of women and men who have been treated with azathioprine before and during conception and pregnancy. There have been no reported instances of birth defects or pregnancy complications that could be associated with this therapy
https://www.drfalkpharma.de/uploads/...2e_12-1-09.pdf
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Mum of 2 kids with Crohn's.
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