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Crohn's Disease Forum » Diet, Fitness, and Supplements » SCD and Paleo Diets » Lack of Mucosal Healing From Modified Specific Carbohydrate Diet in Pediatric Patients With Crohn's Disease


10-08-2017, 08:56 AM   #1
eleanor_rigby
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Join Date: Aug 2012
Location: Cheshire, England, United Kingdom

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Lack of Mucosal Healing From Modified Specific Carbohydrate Diet in Pediatric Patients With Crohn's Disease

http://journals.lww.com/jpgn/Abstrac...ecific.10.aspx
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2nd Generation affected

Symptoms since 2006 (age 17)

Emergency open bowel resection after perforation in 2011 (age 22) (wrongly diagnosed as burst appendix ). Three years remission following this unmonitored

DX with perforating small bowel Crohn's Disease 01/2016 (terminal ileum, duodenum) and coeliac disease (age 26)

Meds:
75mg azathioprine
Gluten-free diet
10-12-2017, 08:37 PM   #2
wildbill_52280
Senior Member
 
Join Date: Sep 2009
Just because clinical activity and biological parameters liek crp decline, doesn't mean youll get much mucosal healing.

Stepwise linear regression identified C reactive protein as predictive of the clinical index, and, successively, alpha 2-globulin, erythrocyte sedimentation rate, faecal alpha 1-antitrypsin, serum orosomucoid, and alpha 1-antitrypsin as predictive of the endoscopic index. Both predictions were poor--the biological variables accounting for only 22 and 44% respectively of the clinical and endoscopic index variations. In conclusion, Crohn's disease clinical activity seems to be virtually independent of the severity of the mucosal lesions and biological activity.
This has been known since 1994 I just came across this study a few weeks ago. https://www.ncbi.nlm.nih.gov/pubmed/7508411/
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http://www.crohnsforum.com/showthread.php?t=52400

Last edited by wildbill_52280; 10-12-2017 at 10:08 PM.
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Crohn's Disease Forum » Diet, Fitness, and Supplements » SCD and Paleo Diets » Lack of Mucosal Healing From Modified Specific Carbohydrate Diet in Pediatric Patients With Crohn's Disease
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