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Crohn's Disease Forum » Tests for IBD » Calprotectin levels


11-28-2017, 06:01 PM   #1
Beautiful-disaster
 
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Calprotectin levels

Hello. I am due to have a colonoscopy in 2 weeks, but I am just curious, would IBS give a reading of 255+ or is it ONLY IBD that have elivated readings? Thank you
11-28-2017, 07:48 PM   #2
Jabee
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To the best of my knowledge IBS does not cause elevated calprotection levels. The test measures the protein calprotectin. I think it is indicative of an increased number of neutrophils in the mucosal surface, which itself indicates inflammation. IBS does not cause inflammation. There are other causes of intestinal inflammation, including infection. Hope this helps.

Last edited by Jabee; 11-29-2017 at 06:43 PM.
11-28-2017, 07:50 PM   #3
scottsma
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Hello and welcome to the forum.Your calprotectin level indicates some inflammation so I would say it's IBD. Your level is not overly high as 50-60 is normal (UK) and many on here have levels in the thousand. G and the dreaded prep....good luck with your colonoscopy and the dreaded prep. we're all happy to help and advise if you need us.
11-28-2017, 08:31 PM   #4
dzwilks
 
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Hello. I am due to have a colonoscopy in 2 weeks, but I am just curious, would IBS give a reading of 255+ or is it ONLY IBD that have elivated readings? Thank you
Hi,
I'm not an expert, but I think you're right that 255 is high for IBS but it's low for untreated IBD. It depends on your age and if your taking NSAID. I found an older woman on a forum who had a similar result but after all the tests it was just IBS.

11-29-2017, 01:50 AM   #5
Guerrero
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I agree with dzwilks, 255 is maybe high for ibs but low for untreated crohn's. You can't conclude you have ibd with one calprotectin test only, there can ben false positive results for many reasons. Endoscopic evidences are needed.
11-29-2017, 06:17 AM   #6
scottsma
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I was diagnosed with Proctitis in 2006 and in the last five years with crohns colitis.My calprotectin level was 400.I have of course has colonoscopy's and biopsies which confirmed crohns.
11-29-2017, 11:48 AM   #7
Beautiful-disaster
 
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Thanks everyone. My 2 results were 255 and 181 but these werenít done at my worst. I have the camera test in 2 weeks I am terrified of them saying nothing is wrong cus I canít deal with this anymore. And yes some people May have readings of over 1000 but that doesnít mean they have worse symptoms or are more poorly, Me with 255 could be a lot worse than someone with 1000.
11-29-2017, 04:08 PM   #8
Guerrero
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I feel sorry for your situation. i'm sure doctors will find a therapy as soon they have All the tests done
11-29-2017, 04:10 PM   #9
Beautiful-disaster
 
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I feel sorry for your situation. i'm sure doctors will find a therapy as soon they have All the tests done
Thank you
11-29-2017, 06:45 PM   #10
Jabee
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Thanks everyone. My 2 results were 255 and 181 but these werenít done at my worst. I have the camera test in 2 weeks I am terrified of them saying nothing is wrong cus I canít deal with this anymore. And yes some people May have readings of over 1000 but that doesnít mean they have worse symptoms or are more poorly, Me with 255 could be a lot worse than someone with 1000.

You are absolutely correct.
11-30-2017, 04:49 AM   #11
scottsma
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It quite common for crohnies to HOPE they find something wrong.It's a sad situation isn't it ?
11-30-2017, 05:56 AM   #12
Beautiful-disaster
 
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Yes it really is! Itís awful. How can someone be so ill and not have a cause....thatís why Iím hoping They find something, itíll make life just that little bit easier
11-30-2017, 08:23 AM   #13
pmadan
 
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Usually what i know if you are already having immune supress medication then stool test for calprotectin is going to be normal. It is one test before colonoscopy. Colonoscopy and biopsy are supreme tests for crohn's
11-30-2017, 08:39 AM   #14
Beautiful-disaster
 
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Iím not on any medication yet. Do they only request a colonoscopy if thereís strong evidence of Crohns? The consultant pressed on my tummy and in 3 areas it was ridiculously painful where he presses down. The top of my tummy, low right and low left
11-30-2017, 09:43 AM   #15
Womble
 
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http://pathlabs.rlbuht.nhs.uk/calprotectin_faecal.pdf

Hope this helps.
The fecal test is a screening tool,to see if you need further tests.
Ibd is just 1 cause of inflammation.
11-30-2017, 09:56 AM   #16
Beautiful-disaster
 
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Thank you, will have a look
11-30-2017, 11:23 AM   #17
Womble
 
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hopefully you will get some answers soon x
11-30-2017, 01:44 PM   #18
The
 
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Is 657 bad, or REALLY bad?

ESR: 54
CRP: 6.2
11-30-2017, 02:50 PM   #19
Guerrero
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Is 657 bad, or REALLY bad?

ESR: 54
CRP: 6.2
Not so good but not dramatic...
12-01-2017, 10:46 AM   #20
OleJ
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A calprotectin (FCC) value of 255 is definitely cause for further investigation. Good luck with the colonscopy. I hope it will give you some conclusions.

Jabee says:I think it is indicative of an increased number of neutrophils in the mucosal surface, which itself indicates inflammation.

Well, I am not so sure that is the case. If we look at chronic gastritis, for example, at least this study finds no significant elevantion in CPP:

CONCLUSION: FCCs were not significantly increased in subjects with chronic gastritis, even in those patients with a marked neutrophil infiltration.


I think it is worth noting this explanation
of how calprotectin has bacteriostatic and fungistatic properties, and is a mechanism that the body uses to try to deal with infectious diseases:


Maybe the role of calprotectin is yet another reason to believe a mycobacterium (aka MAP, more on humanpara.org) infection plays a part in CD, as I previously suggested in this thread.

I'm not on a crusade here, just want to bring this up because I think it has some merit.

Last edited by OleJ; 12-01-2017 at 02:15 PM.
12-01-2017, 10:56 AM   #21
Beautiful-disaster
 
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Thank you very much :-) I will let you all know the outcome. Do you get the results there and then of a colonoscopy or do I have to wait? They havenít booked me in for a consultation after (private csrenthrough NHS in UK)
12-01-2017, 01:38 PM   #22
scottsma
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Your GI might tell you if polyps are there,and he/she will take biopsies if needed.Here in the UK (NHS) we usually wait 4-6 wks for an appt.to discuss findings.Of course,if it's deemed necessary an earlier appt.will be in order.As they say "no news is good news" but that doesn't mean you're out of the woods,only that whatever the diagnosis,it is safe to wait a while.
12-01-2017, 03:04 PM   #23
Beautiful-disaster
 
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Thank you Scott
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