Anti Neutrophil Cytoplasmic Antibodies Test - ANCA
Positive ANCA Subtypes
Within a positive ANCA test result there may be different patterns:
- (c)ANCA - Cytoplasmic ANCA - ANCA staining pattern is throughout the non-nuclear portion of the cell.
- Perinuclear ANCA - ANCA staining pattern is surrounding the nucleus or on the periphery of the nucleus.
- (x)ANCA - Atypical ANCA - ANCA staining pattern of the nuclear periphery which diffuses into a portion of the cytoplasm.
In IBD patients, the (p)ANCA or (x)ANCA staining patterns are typically present.
The positive ANCA result is confirmed by a negative result after DNAse (deoxyribonuclease) treatment.
A positive (p)ANCA test may precede onset of disease in asymptomatic persons. 
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