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Apriso

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About Apriso (mesalamine)

Apriso is a once-daily, extended release, prescription medication used to treat Inflammation in the Colon. It is primarily used for maintaining Remission in adults with Ulcerative Colitis, a type of Inflammatory Bowel Disease (IBD).

5-ASA (Mesalamine), is a long acting version that has an extended release delivery for use in treating Ulcerative Colitis. It is released in the intestines at pH 6 and higher.[1]

It works by decreasing the production of prostaglandins and leukotrienes, chemicals in the lining of the colon that lead to the inflammation of ulcerative colitis. The drug comes in the form of an extended-release capsule and is typically taken once a day. Potential side effects include diarrhea, headache, and nausea.

Apriso can be taken with or without food.

Apriso should NOT be taken with Antacids.

Apriso Side Effects and Adverse Reactions

In Clinical Trials, Adverse Reactions experienced by greater than 3% of patients include the following:
Side Effect / Adverse ReactionApriso (1.5 grams / day)Placebo
Abdominal Pain (Upper)5 %3 %
Diarrhea8 %7 %
Headache11 %8 %
Nasopharyngitis4 %3 %
Nausea4 %3 %
Influenza (Flu) or Flu-like Illness4 %4 %
Sinusitis3 %3 %

Rarely (less than 3%), patients reported the following Adverse Reactions in Clinical Trials:
  • Body as a Whole: Fatigue
  • Ear and Inner Ear: Ringing in the Ears, Dizziness
  • Gastrointestinal: Abdominal Pain (Lower), Rectal Bleeding
  • Kidney (Renal): Decreased Creatinine Clearance, Hematuria
  • Laboratory Tests: Decreased Hematocrit, Decreased Hemoglobin, Increased Triglycerides
  • Liver: Cholestatic Hepatitis, Increased Transaminases
  • Lung (Respiratory): Dyspnea
  • Muscle / Bones: Arthralgia, Pain
  • Skin: Hair Loss
Mesalamine-Induced Acute Intolerance Syndrome
Mesalamine can cause acute intolerance syndrome and the symptoms can be hard to differentiate from the IBD. About 3% of patients are thought to get acute intolerance syndrome. The symptoms may include bloody diarrhea, abdominal pain, cramping, fever, rash, and/or headache. As such, anyone taking Lialda should be closely observed for worsening of these symptoms if they are already present from IBD.

Apriso (mesalamine) Savings Card

Obtain a Savings Card for Apriso (mesalamine) from Salix Pharmaceuticals HERE. Pay the first $25 of your co-payment and receive up to $100 off your Apriso prescription. Find information about Using your Apriso Savings Card HERE. (Apriso Savings card program from TrialCard, Inc.)

References


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10-14-2010, 11:35 AM   #1
Babs1957
 
Join Date: Oct 2010
Location: Cincinnati, Ohio
My GI doc Rx'd Apriso off label for my Crohn's. I take a .375mg capsule 4xday.
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Last edited by Babs1957; 10-19-2010 at 09:39 AM.
10-14-2010, 12:22 PM   #2
girlygirl
Senior Member
 
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Join Date: Sep 2010
Location: Houston, Texas
My GI doc Rx'd Apriso off label for my Crohn's. I take a .375g capsule 4xday.
I am currently taking as well the Apriso 4pills 1x/day 1500mg. My CR Surgeon switched me from 2000mg of Sulfasalazine/day. It appears to have less side effects. My final DX is still uncertain, however, labeled Crohns, possibly Crohns/Colitis.
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GirlyGirl

2010:IBD, CD, Thyroid Nodules, Polyarthralgia; 2015:Gallstones, SBO
Meds: Apriso, Buproprion, B12, Levothyroxine, Lasix, Toprol, Duloxetine, etc
Prev: Traimcinolone, Nystatin, Promethazine, Omeprazole, VIT D, Folic acid, Sulfasalazine, Xifaxin, Zolpidem, Ranitidine, Cipro, Vasculera, Erythromycin, Hydrochlorothiazide, Prednisone, Naproxen, Levocetirizine, Flexeril, Methotrexate, Levaquin, Metronidazole, Tizanidine
Surgery: Abscess/Fistula - Aug2010; GB 2015
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