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Biological therapies

Biological Therapies for Treatment of Crohn's Disease

Biological therapies for the treatment of Crohn's Disease (CD) are among the newest therapeutic agents to be used in Crohn's Disease treatment.

Biological therapies work with the body's Immune System to treat disease. For example, one type of biological therapy utilizes monoclonal antibodies that inhibit the activity (neutralize) Tumor Necrosis Factor (TNF). TNF regulates the immune system, and appears to play some role in inducing Inflammation in disorders such as Arthritis and IBD.

Biological therapies carry serious risks of side effects, including Immunosuppression, increasing a patient's susceptibility to infection.

Current biological therapies approved for use in moderate to severe IBD include Humira, Remicade, Cimzia and Tysabri. Stelara, currently approved for treatment of Psoriasis, is being evaluated for use in Crohn's Disease (Phase III Clinical Trials).

Popular Threads Discussing Biological therapies

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02-15-2012, 12:50 PM   #1
Senior Member
Trysha's Avatar
Join Date: Aug 2009
Hello Rebecca,
Thank you for the information on biological agents, it is very interesting.
02-16-2012, 12:08 AM   #2
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Join Date: Nov 2011
Location: Pennsylvania
Is it supposed to say "reducing" instead of "inducing" inflammation?
02-16-2012, 04:32 AM   #3
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DustyKat's Avatar
Join Date: May 2010
Location: New South Wales, Australia
No, it is mean't to be inducing.

TNF appears to cause inflammation in IBD and the biologics stop/block them from doing this.
Mum of 2 kids with Crohn's.
02-16-2012, 01:20 PM   #4
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Join Date: Nov 2011
Location: Pennsylvania
Ohhh... I gotcha. Thanks
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