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CRP - C Reactive Protein

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C Reactive Protein (CRP)

C Reactive Protein, or CRP, also called PTX1, is released by the liver early in active Inflammation and can be used as a Serological marker to indicate the degree of Active Inflammation in the body.[1]

CRP levels can be determined by Blood Test and is part of the Prometheus Inflammatory Bowel Disease Diagnostic Panel, Prometheus IBD sgi Diagnostic.

However, CRP levels are in indicator of Generalized Inflammation in the body and are NOT specific for Inflammatory Bowel Disease

CRP Levels

Higher levels of CRP are usually seen in Crohn's Disease (CD) versus Ulcerative Colitis (UC) (UC).[3]

CRP increases in response to Interleukin 6 (IL-6), Interleukin-beta (IL-B), Tumor Necrosis Factor-alpha (TNF-a /TNF-α).[4]

Crohn's patients with high CRP levels have a higher incidence of Relapse / Flares than patients that have normal CRP serum levels. [5]

The Sensitivity and Specificity of CRP Test results in predicting Relapse Rates are 54% - 75% and 45% - 90%, respectively.[5]

CRP Mutation

In CRP gene mutations involving Crohn's disease (CD), symptoms are correlated with Ileal involvement.[2]

References

1. Thalmaier D, Dambacher J, Seiderer J, et al. The +1059G/C polymorphism in the C-reactive protein (CRP) gene is associated with involvement of the terminal ileum and decreased serum CRP levels in patients with Crohn's disease. Alimentary Pharmacology & Therapeutics. 2006;24(7): 1105-1115. http://onlinelibrary.wiley.com/doi/1...06.03093.x/pdf

2. Epameinondas V Tsianos, Konstantinos H Katsanos, and Vasileios E Tsianos. Role of genetics in the diagnosis and prognosis of Crohn's disease. World J Gastroenterol. 2012;18(2): 105-118. http://www.ncbi.nlm.nih.gov/pmc/arti....pdf/?tool=EBI

3. Prometheus Monograph

4. Vermeire S, Van Assche G, Rutgeerts P. Laboratory markers in IBD: useful, magic, or unnecessary toys? Gut. 2006;55(3):426-431.

5. Yonal O, Kaymakoglu S. How should we follow the Crohn’s disease patients in remission? The Turkish Journal of Gastroenterology. 2010; 21(1): 97-99. http://www.turkgastro.org/pdf/789.pdf

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