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Cipro - Ciprofloxacin

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About Cipro (Ciprofloxacin Hydrochloride / Ciprofloxacin)

Ciprofloxacin, also known as Cipro, is a Synthetic, Broad Spectrum, Fluoroquinolone - Type Anti - Bacterial Antibiotic.[2] Cipro can be used in the treatment of IBD and Small Intestine Bacterial Overgrowth. It has been shown to be as effective as mesalamine in the treatment of Crohn's Disease.[1]

Cipro is found in multiple areas of the body within hours after oral dosing including: urine, saliva, sinus secretions, bile, prostate, lung, skin, bone, muscle and cartilage. Cipro can be found in brain and spinal fluids, but at lower levels than found in the bloodstream (10% or less than levels in the blood). Low levels can also be found in fluids of the eye. [2]

How Does Cipro Work?

Ciprofloxacin kills bacteria by impairing Enzymes (specialized Proteins) necessary for DNA reading, unwinding, repair, and replication.

What Does Cipro Treat?

Ciprofloxacin is primarily used for treatment of Aerobic Bacterial infections including:
Enterococcus sp.
Staphylococcus sp.
Streptococcus sp.
Campylobacter sp.
Citrobacter sp.
Escherichia coli
Haemophilus influenzae
Haemophilus parainfluenzae
Klebsiella pheumonia
Legionella pneumophila
Neisseria gonorrhoeae
Salmonella sp.
Pseudomonas aeruginosa (*Can become resistant quickly)
Serratia marcescens
Shigella sp.
Yersinia enterocolitica

Most Anaerobic bacterial infections are resistant to Cipro, including Clostridium difficile. [2]

Cipro is used for Multiple different types of Infections which Include:
Abdominal Infections (in combination with Flagyl - Metronidazole)
Anthrax
Bone and Joints
Diarrhea (caused by Bacterial Infection)
Gonorrhea
Prostate
Sinus
Skin
Typhoid Fever (Enteric Fever)
Unirary Tract Infections / Cystitis

Warnings

Cipro should not be used in patients that have a history of hypersensitivity to Cipro (Ciprofloxacin) or other Quinolone - based products.

Patients with kidney disease may have a reduced ability to excrete Cipro. [2]

Elderly persons will often have increased levels of Cipro in the body. This may be due in part to a decreased ability to eliminate the drug. [2]

Do not skip doses and make sure to take all prescribed doses even if you are feeling better.

When Cipro Tablets are taken with food, there is a delay in absorption of the Antibiotic. This delay is not seen when the Cipro Suspension (Liquid) is taken with food. [2]

Cipro, when used in Children / Pediatric age groups, can cause Bone Joint abnormalities. Cipro is not typically used as a first choice Antibiotic in Children.

Cipro Drug Interactions

Cipro is known to inhibit Cytochrome P4501A2 (CYP1A2) metabolism. Other medication metabolized by CYP1A2, when taken during Cipro treatment, may not be metabolized as well. This can lead to increased levels of either medication, and can reach Toxic levels.

Probenecid

Cipro availability is reduced substantially (as much as 90%) if it is taken with Magnesium Hydroxide or Aluminium Hydroxide containing Antacids. Taking these type of Antacids with Cipro is not recommended.

Cipro will inhibit the body's metabolism of Caffeine.

Calcium

Theophylline

Tizanidine

References


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