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Entocort

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About

Budesonide, brand name Entocort or Entocort EC (Enteric Coated) is one of the Steroids commonly used to treat acute flare ups of IBD. It is the main alternative to Prednisone. Budesonide is a 'milder' drug. It has a more focused effect in the Gastrointestinal Tract, and doesn't affect the whole body to the extent seen with many other Steroid-based therapies. It is absorbed in the terminal ileum and ascending (right sided) colon. Therefore it is not suitable for treating disease in other areas. Side effects are less common, but it may not treat severe flares as effectively as prednisone. The brand name drug, Entocort, is also more expensive although a generic form of Budesonide is available.[4]

Budesonide in Ulcerative Colitis

A Cochrane review found Budesonide to be less efficacious than 5-ASA (Mesalamine) formulations and does not recommend the use of Budesonide in Ulcerative Colitis.[1]

Side Effects

The following side effects have been reported by those taking Entocort:
  • sore throat
  • nose irritation or burning
  • bleeding or sores in the nose
  • rash
  • upset stomach
  • cough
  • bad taste in mouth
  • hoarseness
  • dry mouth
  • change in mucus color
  • lightheadedness
  • muscle cramps
  • difficulty breathing or swelling of the face
  • white patches in the throat, mouth, or nose
  • irregular menstrual periods
  • severe acne

Entocort and Pregnancy and Nursing

Entocort EC is a Pregnancy Category C medication.[3] This means that animal reproduction research studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks. View the Pregnancy Categories for Drugs wiki page for more medications and their Pregnancy Categories.

The Clinical Monograph for Entocort EC cites a study investigating Inhaled Budesonide (treatment for Asthma) in Nursing Mothers. This study shows inhaled Budesonide is excreted in milk. Although there are no studies investigating Entocort EC and Nursing mothers, and the dosage is higher when using Budesonide for Crohn's Disease than the inhaled form used for Asthma treatment, there may be more Budesonide released in breast milk in Crohn's treatment and is not recommended for use in nursing mothers as it may cause harm to the baby.[3]

References


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