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Fecal Transplant

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Fecal Transplant (Faecal Transplant)

What is Fecal Transplantation Therapy?


Fecal transplantation therapy is a procedure where a stool sample from a donor (usually a family member) is inserted into the patient in order to introduce a healthy balance of Gastrointestinal (GI) microbes into the patient.

Why is Gastrointestinal Microbial Balance Important?


There are a number of disorders that can be caused, exacerbated, or result in Dysbiosis, or an imbalance in the body's normal microbes, including: Diabetes, Metabolic Syndrome, Irritable Bowel Syndrome (IBS), Inflammatory Bowel Disease (IBD), and Antibiotic treatment.

Microbial Imbalance of the GI Tract can allow dangerous bacteral species such as Clostridium difficile (C. diff) to overgrow. C. diff infections can be dangerous, even fatal.

Certain GI Tract bacterial species are known to produce Vitamin K. Whether bacterial Vitamin K production is clinically relevant is a matter of debate.

Different Methods of Modifying Microbial Balance


In order to introduce a proper balance of GI Tract microbes, including beneficial microbes, a number of strategies have been used.
Probiotics

Probiotics are often used to influence levels of beneficial microbes.

- Unfortunately, probiotic treatments often have a clinically variable outcome, but most treatments see slight if any benefit.

- The diversity of microbial species introduced with probiotic treatment is limited and not representative of the largely diverse species seen in the healthy GI Tract.
Lessons from Ruminants
Fecal Transplantation Therapy

Fecal Transplantation Therapy has been performed with positive results in patients with Clostridium difficile (C. diff) Infection, Constipation, Irritable Bowel Syndrome (IBS), Crohn's Disease (CD) and Ulcerative Colitis (UC).

The basis for this treatment is that restoring the balance of healthy bacteria in a person's gut can eliminate or improve conditions and diseases that were caused by the unhealthy pathogens.

The Centers for Disease Control (CDC) Division of Healthcare Quality states that Fecal Transplantation Therapy shows promise in preventing Multidrug-Resistant Organisms (MDRO) that can occur with antibiotic treatment and Clostridium difficile Infections (CDI) which can be severe. [2]

Interest in this treatment is growing as it is much simpler and less invasive form of treatment compared to any surgery option.

Clinical Trials for Fecal Transplant Therapy

Clinical Trial to Investigate Fecal Transplantation Therapy in Pediatric Patients with IBD.
http://clinicaltrials.gov/ct2/show/N...ases%22&rank=7

References

1. Landy, J., Al-Hassi, H. O., McLaughlin, S. D., Walker, A. W., Ciclitira, P. J., Nicholls, R. J., Clark, S. K. and Hart, A. L. (2011), Review article: faecal transplantation therapy for gastrointestinal disease. Alimentary Pharmacology & Therapeutics, 34: 409415. http://onlinelibrary.wiley.com/doi/1...11.04737.x/pdf

2. McDonald C. Using fecal transplants to treat Clostridium difficile infections (CDI). Safe Healthcare, CDC. January 2012. Accessed June 2012. http://blogs.cdc.gov/safehealthcare/?p=2219

3. Emery G. Feces transplant may help relieve severe diarrhea. Reuters Health Information. MedlinePlus. January 16, 2013. Accessed January 2013. http://www.nlm.nih.gov/medlineplus/n...ry_133165.html

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03-02-2013, 08:16 AM   #1
Kinsey
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Join Date: Feb 2013
Location: Virginia
Now, we just have to transter back to Fairfax Inova after I verify that they can do the procedure. My son is refusing to go to the local lab for another test, actually he just always says he's too tired. But I know there's more to it than that. He's starting to realize he's not welcome at some people's house's because of the C-Diff.

Last edited by Kinsey; 03-03-2013 at 10:51 AM.
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