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IL10 - Interleukin 10

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About Interleukin 10

Interleukin 10, or IL10, is a Cytokine that functions to down-regulate or suppress the Immune Response. Most notably, IL10 limits secretion of the ProInflammatory Cytokines, IL12 - Interleukin 12 and TNF - Alpha.

The Interleukin 10 Gene Expression has been shown to be deregulated in certain forms of Inflammatory Bowel Disease and can play a role in Crohn's Disease and Ulcerative Colitis.
Mouse Model of IBD - IL10 Knockout Mouse
A mouse model of IBD has been developed by deletion of IL10 or the IL10 Receptor (IL10 Knockout Mouse). [2][3]

Other Cytokines in IBD

Check out the Wiki page listing other Cytokines involved in IBD HERE.

References

1. Glocker E-O, Kotlarz D, Boztug K, et al. Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor. N Engl J Med. 2009; 361: 2033-2045. http://www.nejm.org/doi/pdf/10.1056/NEJMoa0907206

2. http://www.tno.nl/downloads/Innovati...harmaS03B4.pdf

3. Leach MW, Davidson NJ, Fort MM, Powrie F, and Rennick DM. The Role of IL-10 in Inflammatory Bowel Disease: "Of Mice and Men". Toxicol Pathol. 1999; 27: 123-133. http://tpx.sagepub.com/content/27/1/123.full.pdf

4. Wilson MS, Ramalingam TR, Rivollier A, Shenderov K, Mentink–Kane MM, Madala SK, Cheever AW, Artis D, Kelsall BS, Wynn TA. Colitis and Intestinal Inflammation in IL10−/− Mice Results From IL-13Rα2–Mediated Attenuation of IL-13 Activity. Gastroenterology. 2011; 140(1): 254-264. http://www.gastrojournal.org/article...456-3/abstract and http://www.ncbi.nlm.nih.gov/pmc/arti...ihms246590.pdf

5. Paul G, Khare V. Gasche C. Inflamed gut mucosa: downstream of interleukin-10. Eur J Clin Invest. 2012; 42(1):95-109. http://onlinelibrary.wiley.com/doi/1...11.02552.x/pdf

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