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IL12 - Interleukin 12

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Interleukin 12- IL-12

Interleukin 12 (IL12), also called Natural Killer Cell Stimulatory Factor (NKSF) or Cytotoxic Lymphocyte Maturation Factor (CLMF). IL12 is produced by the immune cells, macrophages and B lymphocytes in response to microbial infection.

Interleukin 12 in Crohn's Disease

In Crohn's Disease, IL12, or Interleukin 12, is produced inappropriately by immune cells (B - cells and macrophages) causing an increase in Inflammatory Factors (pro-inflammatory Cytokines) that further stimulate the immune response. These factors, in turn propagate the inflammation by stimulating the production of more inflammatory factors, leading to the vicious cycle of inflammation seen in Crohn's disease.

IL12 increases production of:
-IFN - gamma
-TNF - Tumor Necrosis Factor
-IL2 - Interleukin 2
-activates cytotoxicity and proliferation of NK (Natural Killer) cells
-activates cytotoxicity and proliferation of T cells
-Together, IL12 and PHA- Phytohemagglutinin cause proliferation of lymphoblasts (immature immune cells).

Other Cytokines in IBD

Check out the Wiki page listing other Cytokines involved in IBD HERE.

References


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