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Prometheus IBD sgi Diagnostic

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Prometheus IBD sgi Diagnostic

Prometheus Therapeutics & Diagnostics offers testing services to help your doctor determine if you have Crohn's Disease (CD) or Ulcerative Colitis (UC), Inflammatory Bowel Disease (IBD) or non-Inflammatory Disease (non-IBD). This test uses a blood sample and looks for disease-specific (or disease-typical) markers for Serology, Genetics, and Inflammation and is also known as the Prometheus IBD SGI Diagnostic.

Prometheus IBD sgi Diagnostic Components

Serological Tests
Serological Tests by ELISA:
- ASCA - Anti-Saccharomyces Cerevisiae Antibodies Test IgA
- ASCA - Anti-Saccharomyces Cerevisiae Antibodies Test IgG
- Anti-OmpC IgA
- Anti- CBir1
- Anti-A4-Fla2 IgG
- Anti-FlaX IgG
- AutoAntibody

Serological Tests, Other:
- IFA Perinuclear Pattern
- DNAse Sensitivity
Genetic Tests
Tests for Presence of SNPs:
- ATG16L1 - Autophagy Related 16 Like 1 SNP (rs2241880)
- EMC1 SNP (rs3737240)
- NKX2-3 SNP (rs10883365)
- STAT3 SNP (rs744166)
Inflammatory Tests
- ICAM-1
- VCAM-1
- VEGF
- CRP - C Reactive Protein
- SAA

What Does a Typical Prometheus IBD sgi Diagnostic Report Look Like?

Current Procedural Terminology (CPT) Codes for Billing and Insurance Submission

From Prometheus Therapeutics & Diagnostics, Prometheus Laboratories Inc.[1]
- 83520(X8), ELISA; antibody specific for each serology bio-marker (see above)
- 82397(X3), ICAM, VCAM, SAA Chemiluminescent Assay
- 86140(X1), CRP
- 88347(X2), IBD Specific pANCA; Indirect Immunofluorescent assay, IgG specific & DNAse sensitivity
- 83907(X1), Lysis of cells prior to nucleic acid extraction
- 83898(X4), PCR, DNA Markers ATG16L1, ECM1, NKX2-3, STAT3
- 83896(X8), Nucleic acid probes
- 83912(X1), Interpretation and report

Other Relevant Prometheus Laboratories IBD Tests

Prometheus Laboratories also offers testing for specific gene mutations in NOD2 / CARD15, the most common gene mutation that correlates with Crohn's Disease. This test is seperate from the Prometheus IBD sgi Diagnostic (above) and is called Prometheus NOD2 / CARD15 Test.

References

1. Prometheus Therapeutics & Diagnostics. Prometheus Laboratories Inc.

2. Chidlow, Jr., Shukla, Grisham et al. Pathogenic angiogenesis in IBD and experimental colitis: new ideas and therapeutic avenues. American Journal of Physiology.Gastrointestinal and Liver Physiology. 2007;293:G5-G18. http://ajpgi.physiology.org/content/293/1/G5.full.pdf

3. Cummings, Cooney, Pathan et al. Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility gene. Inflammatory Bowel Diseases. 2007;13:941-946. http://eorder.sheridan.com/3_0/displ...lashprint=1427

4. Fleshner, Ippoliti, Dubinsky et al. Both Preoperative Perinuclear Antineutrophil Cytoplasmic Antibody and Anti-CBir1 Expression in Ulcerative Colitis Patients Influence Pouchitis Development After Ileal Pouch–Anal Anastomosis Clinical Gastroenterology and Hepatology. 2008: 6:561-568. http://digitalreprints.elsevier.com/issue/45881

5. Henriksen, Jahnsen, Lygren et al. C-reactive protein: a predictive factor and marker of inflammation in inflammatory bowel disease. Results from a prospective population-based study. Gut. 2008;57:1518-1523.

6. Meggyesi, Kiss, Koszarska et al. NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients. World J.Gastroenterol. 2010;16:5233-5240. http://www.wjgnet.com/1007-9327/16/5233.pdf

7. Sandborn, Loftus, Colombel, et al. Evaluation of serologic disease markers in a population-based cohort of patients with ulcerative colitis and Crohn's disease. Inflammatory Bowel Diseases. 2001; 7:192-201. http://eorder.sheridan.com/3_0/displ...lashprint=1429

8. Schoepfer, Schaffer, Mueller et al. Phenotypic associations of Crohn's disease with antibodies to flagellins A4-Fla2 and Fla-X, ASCA, p-ANCA, PAB, and NOD2 mutations in a Swiss Cohort. Inflammatory Bowel Diseases. 2009;15:1358-1367. http://eorder.sheridan.com/3_0/displ...lashprint=1428

9. Targan, Landers, Yang et al. Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology. 2005;128:2020-2028. http://digitalreprints.elsevier.com/issue/45899

10. Thompson, Lees. Genetics of ulcerative colitis. Inflammatory.Bowel Diseases. 2011;17:831-848. http://eorder.sheridan.com/3_0/displ...lashprint=1426

11. Lees, Satsangi. Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history. Expert Rev.Gastroenterol.Hepatol. 2009;3:513-534. http://www.prometheuslabs.com/Resour...patol_p513.pdf

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