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Vedolizumab

Vedolizumab, an investigational drug also called MLN0002, is a new anti-adhesion form biologic drug which is currently in Phase III Clinical Trials to to treat IBD. Anti-adhesion drugs operate differently to traditional TNFα drugs, but use the similar Biologic Antibody Based.

Vedolizumab, from Millennium Pharmaceuticals, is a Biologic Drug which acts by blocking the binding between α4β7 Integrin and Mucosal Adressin Cell Adhesion Molecule-1 (MADCAM-1).

Vedolizumab is a newer version of the less specific biologic drug, Tysabri (Natalizumab), which blocked all α4 Integrins.

The more specific design of Vedolizumab is expected to have a more specific effect in the Gastrointestinal (GI) Tract.

Vedolizumab (MLN0002) Phase III Clinical Trial

Phase III Clinical Trial of Vedolizumab (MLN0002) for Crohn's Disease and Ulcerative Colitis

An Open-label Study of Vedolizumab (MLN0002) in Patients With Ulcerative Colitis and Crohn's Disease (GEMINI LTS)

One doctor has written a paper stating they feel Vedolizumab should not be approved due to side effects that are being reported in trials.

References

Baumgart, D. C. (2010), Veto on vedolizumab (MLN0002) for Crohn's disease. Inflamm Bowel Dis, 16: 537538. doi: 10.1002/ibd.21078 http://onlinelibrary.wiley.com/doi/1.../ibd.21078/pdf

Feagan, B. G. and Parikh, A. (2010), Response to Baumgart review. Inflamm Bowel Dis, 16: 1449. doi: 10.1002/ibd.21201 http://onlinelibrary.wiley.com/doi/1.../ibd.21201/pdf

http://www.takeda.com/press/article_45691.html

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