Share Facebook
Crohn's Disease Forum » Forum Wiki » Xifaxan - Rifaximin


Xifaxan - Rifaximin

Contents


About Xifaxan (Rifaximin)

Xifaxan, also called Rifaximin, from Salix Pharmaceuticals, Inc. is a drug used for treatment in multiple Gastrointestinal (GI) diseases related to bacterial overgrowth or imbalance.

Xifaxan / Rifaximin is typically used in treatment of:
- Irritable Bowel Syndrome (IBS)
- IBS-D and mixed / alternating IBS (Not C Type IBS)
- Crohn's Disease (CD)
- Ulcerative Colitis (UC)
- Diverticulitis
- SIBO (Small Intestinal Bacterial Overgrowth)
- Travelers' Diarrhea (TD)
- Hepatic Encephalopathy (HE; a liver disease that can cause GI bacterial overgrowth)

Rifaximin was sold in Italy since 1985 by Alfa Wassermann Pharmaceuticals under the name Normix.

In 2004, Xifaxan (Rifaximin) was approved in the United States for Traveler's Diarrhea (TD).

How Does Xifaxan / Rifaximin Treat Bacterial Overgrowth

Alterations in the microbiome of the GI Tract (imbalance and/or overgrowth) can lead to an Inflammatory response in the patient. These inflammatory reactions in some cases can be ineffective in normalizing the GI Tract microbiome and lead to symptoms that are chronic, destructive and/or severe.[1][2][3][4] Certain pathogenic strains of bacteria can produce toxins and lead to inflammation, diarrhea, or tissue destruction.

Xifaxan (Rifaximin) is an antibiotic derived from Rifamycin. It is effective against Gram positive and Gram negative bacteria that are aerobic or anaerobic. The mechanism of antibiotic action is via inhibitionn or bacterial RNA synthesis.[5]
Xifaxan (Rifaximin) is Considered a "Locally Acting Antibiotic"
Xifaxan (Rifaximin) has an extremely low solubility in water resulting in poor intestinal absorbtion. As a result, the drug's primary activity remains within the GI tract and is not distributed systemically (throughout the entire body).[5]

The advantages of a "Locally Acting Antibiotic" can be seen in reduced side effects and a lower prescribed dosage than would be expected if the antibiotic were distributed throughout the body.

Financial Assistance Programs for Xifaxan / Rifaximin Antibiotic

Salix Pharmaceuticals, Inc. Patient Assistance Program
Salix Pharmaceuticals, Inc. offers Patient Assistance Programs for persons unable to afford their medication. For more information, please visit: Salix Pharmaceuticals, Inc. Patient Assistance Program or call: 1-866-282-6563 (EST USA)[6]
Salix Pharmaceuticals Patient Assistance Program for Xifaxan / Rifaximin 550 mg Tablets. * Check to see if you qualify before shelling out your cash.

Website:
http://www.salix.com/about-us/corpor...ssistance.aspx

Form to be Filled Out:
http://www.salix.com/assets/pdf/phar...pplication.pdf

Patient Assistance Program Telephone Number: 1-866-282-6563

Medications Covered by Salix Pharmaceuticals Patient Assistance Program:

Apriso / mesalamine Extended-release Capsules .375 g
Azasan / Azathioprine Tablets, USP 75 mg
Azasan / Azathioprine Tablets, USP 100 mg
Colazal / balsalazide disodium Capsules 750 mg
Metozolv ODT / metoclopramide HCI Tablet 5 mg
Metozolv ODT / metoclopramide HCI Tablet 10 mg
Relistor / methylnaltrexone bromide Subcutaneous Injection 0.6 mL
Xifaxan / Rifaximin 550 mg Tablets
Request Free Samples of Xifaxan / Rifaximin Salix Pharmaceuticals, Inc.
Salix Pharmaceuticals has a webpage that your doctor can fill out and obtain free samples of Xifaxan / Rifaximin from their Sales Representative. I think it is reasonable to ask your doctor. If you explain the cost for a 2 week supply can be around $1000, hopefully they will be willing to help you out.
https://www.salix.com/products/request-samples.aspx
Xifaxan 550mg Reimbursement Program by Salix Pharmaceuticals, Inc.

*Make sure you know if you qualify of not before filling your Xifaxan / Rifaximin Prescription.
Instructions for Forms:
http://www.salix.com/assets/pdf/phar...structions.pdf

Telephone Number: 1-866-XIFAXAN

Important Things To Ask:
- What Diagnosis Codes Qualify for the Reimbursement Program?
- Is the ICD-9 Code Required for Reimbursement and Do You Qualify under ICD-9 Code Status (according to your physician)?

Phone: 1-866-XIFAXAN
Fax completed Form to: 800-387-5807 1-866-943-2926

Website for More Information:
www.Xifaxan550helpline.com
and
http://www.xifaxan550.com/hcp/physic...#reimbursement
What to do if Your Xifaxan / Rifaximin Claim is Denied
In the event your Xifaxan / Rifaximin Claim is Denied Salix Pharmaceuticals Inc. has free support services that may be able to help [9]:

- Free Support Service Telephone Helpline for Patients, Physician, or Physician's Office Personnel: 1-866-XIFAXAN 1-866-943-2926 Xifaxan 550 mg Reimbursement Helpline. This Free Support Helpline connects you to trained reimbursement analysts that will help negotiate with your insurance company, appeal denied claims, and answer questions.

- Services Offered through Telephone Support Helpline:
- Receiving current reimbursement policies for private payers, Medicaid, and Medicare

- Verifying individual patient coverage

- Verifying insurance coverage associated with the patient assistance program

- Assisting with prior authorizations

- Managing negotiation of appeals on denied claims

- Receiving customized information to assist with coverage or appeals

- Hours for Telephone Support Helpline: 8:30 am–5:30 pm EST Monday through Friday.
Salix Pharmaceuticals Inc. Rebate Card Program
Salix Pharmaceuticals, Inc. Rebate Card Program.[10]

Rebate Card Program Informational Website (Salix Pharmaceuticals).
http://www.xifaxan550.com/hcp/physic...#reimbursement

OR

Rebate Card Program Telephone Support. Call a Representative to Obtain Rebate Card Program Information:
Call: 1-866-669-SLXP (1-866-669-7597).

References

1. Xifaxan (Rifaximin) Tablets, 550 mg NDA 21-361. Briefing Document for Gastrointestinal Drugs Advisory Committee Meeting 23 February 2010. Accessed May 2012. http://www.fda.gov/downloads/Advisor.../UCM201081.pdf

2. Xifaxan (Rifaximin) Tablets, 550 mg NDA 21-361. Errata to Briefing Document for Gastrointestinal Drugs Advisory Committee Meeting 23 February 2010. Accessed May 2012. http://www.fda.gov/downloads/Advisor.../UCM201082.pdf

3. Xifaxan (Rifaximin) Tablets, 550 mg NDA 21-361. Briefing Document for Gastrointestinal Drugs Advisory Committee Meeting 16 November 2011. Accessed May 2012.
http://www.fda.gov/downloads/Advisor.../UCM279646.pdf

4. Xifaxan (Rifaximin) Tablets, 550 mg NDA 21-361. Errata to Briefing Document for Gastrointestinal Drugs Advisory Committee Meeting 16 November 2011. Accessed May 2012.
http://www.fda.gov/downloads/Advisor.../UCM279648.pdf

5. Gastrointestinal Drugs Advisory Committee Background Package. 16 November 2011. Accessed May 2012. http://www.fda.gov/downloads/Advisor.../UCM279643.pdf

6. Salix Pharmaceuticals, Inc. Patient Assistance Program. Accessed May 2012. http://www.salix.com/about-us/corpor...sistance.aspx]

7. Wehrli W, Knüsel F, Schmid K, Staehelin M. Interaction of rifamycin with bacterial RNA polymerase. Proc Natl Acad Sci U S A. 1968; 61(2): 667–673. http://www.ncbi.nlm.nih.gov/pmc/arti...00124-0313.pdf

8. Peralta S, Cottone C, Doveri T, Almasio PL, Craxi A. Small intestine bacterial overgrowth and irritable bowel syndrome-related symptoms: Experience with Rifaximin. World J Gastroenterol. 2009; 15(21): 2628-2631. http://www.wjgnet.com/1007-9327/15/2628.asp

9. Reimbursement Help for Xifaxan / Rifaximin Salix Pharmaceuticals, Inc. Claims. http://www.xifaxan550.com/hcp/physic...#reimbursement

10. Rebate Card Program Informational Website (Salix Pharmaceuticals).
http://www.xifaxan550.com/hcp/physic...#reimbursement

11. NORMIX IN CROHN'S DISEASE. http://pheniciagroup.com/articledeta...p?ArticleID=36

Popular Threads Discussing Xifaxan



Page Tools
No one has commented on this article.

Reply
Page Tools
Search this Page


All times are GMT -5. The time now is 09:42 AM.
Copyright 2006-2017 Crohnsforum.com