A New Care Plan for Crohn’s Disease

Combined treatments helped heal patients with Crohn’s disease

Septic perianal Crohn’s disease is a complication that has long been difficult to treat, but a new type of care plan may help.
Researchers at Penn State College of Medicine spent more than 10 years developing and testing a care plan that helps doctors decide how and when to treat patients with septic perianal Crohn’s disease.

Crohn’s disease is one of several inflammatory bowel disorders. Patients have severe abdominal cramping, bleeding and diarrhea. About 41 percent of patients with Crohn’s disease develop infected abscesses that become fistulas–open wounds that are very difficult to treat.

At one time surgery was the preferred treatment, but a medication called infliximab, know by the brand name Remicade, helped suppress the inflammatory condition in about 59 percent of patients. After a year, however, only 25 percent of the patients still experienced healing.

“What was thought to be a silver bullet of sorts for this problem really is not,” lead author Walter A. Koltun, MD, said in a press release.

Dr. Koltun is a professor of surgery at Penn State College of Medicine.

Despite the expense and possibility of significant side effects, many patients with Crohn’s disease stay on infliximab through fear the condition will become worse if they stop the medication. Dr. Koltun and colleagues have developed a care plan that helps doctors determine whether and when to continue the medication or to move to a surgical solution. The care plan is the first of its kind.

An analysis of 135 episodes of septic perianal Crohn’s disease found that 60 percent of the patients treated with the new care plan healed and remained healed for at least six months. Half of the remaining patients improved, but did not heal completely. The remainder did not heal and required surgery.

The researchers also analyzed genetic variations to see how they might affect healing, but results were not statistically significant.

“What we did with this study is look at a combined medical and surgical protocol for managing this problem, recognizing that there’s a role for the medicines, and there’s a role for the surgery,” Dr. Koltun said in the press release. “Our protocol provides a paradigm for when you perhaps should stop the drug and when to consider surgery with or without medication.”

The research and care plan were published in the June issue of the Journal of the American College of Surgeons.

Funding for the care plan was provided by the Carlino Fund for Inflammatory Bowel Disease Research.

None of the authors reported a conflict of interest.

An article from dailyrxnews, by Matt Wilson

  • Lopez Ma

    I have lived with Crohn’s for 40 years and was diagnosed at 14, doctors told my parents I would not make it by 22 and they were right at 20 I was doing my first life saving operation. I did not want to sign the consent for this operation and I wish I had not signed it. I have gone through 49 surgeries 3 life saving. My body is no longer functioning, the pain is constant, I have no quality of life, the lethargy does not allow me to do much and I have to go to the toilet 15 times a day. I had to stop working, I am depending on others. To put the icing on the cake I respond to no medication, I have a stenosis and 3 fistulae non operable. I have decided that death is a better option, the most humane. So I have arranged an assisted death and I am looking forward to put an end to my misery.