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Recent content by kiny

  1. kiny

    Calprotectin elevated again

    In the 1980s, Belgian GI and surgeon Rutgeerts said it aptly: "To cut is not to cure", meaning a surgical intervention generally does not keep the disease at bay. The Crohn's "Rutgeerts score", which is still used today, is named after him, which predicts crohn's recurrence in patients. If you...
  2. kiny

    Daily consumption of fruit/vegetables in OECD countries and crohn's disease prevalence.

    Another thing, probiotics are not "harmless". Infections following use of over-the-counter probiotics are well documented and more common than people realise, in both children and adults. When people with crohn's disease come onto this forum seeking advice regarding colonoscopy results...
  3. kiny

    Daily consumption of fruit/vegetables in OECD countries and crohn's disease prevalence.

    Koch's postulates exist to avoid a dangerous thought process, to avoid creating situations where patients would end up being guinea pigs as a result of bad conclusions. Dysbiosis is a common feature of any inflammatory reaction to antigen, certain bacteria bloom under inflammatory conditions...
  4. kiny

    Daily consumption of fruit/vegetables in OECD countries and crohn's disease prevalence.

    Billions of have been spent on microbiome research, probiotics, prebiotic and fecal tranplant research. It has not helped a single person with crohn's disease. People with crohn's disease are not guinea pigs, there's no room for "trial and error". These are errors and experiments people with...
  5. kiny

    Daily consumption of fruit/vegetables in OECD countries and crohn's disease prevalence.

    EN, highly processed and completely lacking in fiber, leads to 85%+ remission rates, often including fistula closure. Fiber-rich "natural" plant diets do not lead to remission. The "good bugs" theory failed. Probiotics don't work. Prebiotics don't work. Fecal transplants lead to disastrous...
  6. kiny

    1973. Intravenous alimentation.

    MRI and ultrasound are cross-sectional, they can show increased wall thickness indicating inflammation. You compare wall thickness on the slide with other parts of the intestine, and you can literally measure it, below 3mm is normal, above 4mm indicates disease activity. But only colonoscopies...
  7. kiny

    1973. Intravenous alimentation.

    It's very possible that the innate immunodeficiency stage presented in crohn's dsiease is actually quite minor. We don't tend to have major issues clearing non-GI infections. But when the epithelial barrier is compromised after chronic inflammation due to innate immunodeficiencies, large...
  8. kiny

    1973. Intravenous alimentation.

    Macrophages are the immune cells of the innate immune system. They're very important in crohn's disease, they are the primary defense when microbes manage to get past our first defense, the physical intestinal barrier made up of the mucus layer and epithelial cells. Pathogens will encounter...
  9. kiny

    1973. Intravenous alimentation.

    Crohn's disease involves a defective innate immune response. You can see this from the susceptibility loci. NOD2 and ATG16L1 mutations hinders competent authophagy required for clearance of intracellular pathogens. ATG16L1, or Autophagy related 16 like 1. Most people know autophagy can be...
  10. kiny

    1973. Intravenous alimentation.

    Those studies where multiple macrophage penetrating antibiotics are successfully used to induce remission for months in crohn's disease patients, the so-called antibiotic cocktails, likely are effective. But you're exposing patients to an aggressive course of antibiotics, you require 3 or 4...
  11. kiny

    1973. Intravenous alimentation.

    Rifaximin is only advised for noninvasive E coli like travellers diarrhoea. Rifaximin is non-systemic, unable to penetrate activated tissue macrophages in crohn's disease, so I don't understand the intention of that study. In crohn's disease you have chronically activated lamina propria...
  12. kiny

    1973. Intravenous alimentation.

    Not sure, but discussions regaring crohn's disease clearly went completely off track after the 1970s. During the 90s and 2000s, crohn's disease was referred to by GI as an "overreactive immune system" without any proof. GI were adamant that dietary manipulation was useless. Pathogens didn't...
  13. kiny

    Specific pathobionts are enriched during flares in patients with severe CD

    "Pathobionts" is an awful recently invented term. Pathobionts are just pathogens, every pathogen is conditionally invasive. The term if often used to shield microbiome research when it turns out the microbiome is not as harmless as initially assumed, and includes a lot of unknown and invasive...
  14. kiny

    Specific pathobionts are enriched during flares in patients with severe CD

    Specific gut pathobionts escape antibody coating and are enriched during flares in patients with severe Crohn’s disease 2024 Feb 23 Department of Biotechnology and Biomedicine, Technical University of Denmark Objective Patients with Crohn’s disease (CD) exhibit great heterogeneity in...
  15. kiny

    1973. Intravenous alimentation.

    I would like to know what happened with GI and research between the 70s and today. TPN is from 1960 when Stanley Dudrick introduced it in clinical practice. In the 70s doctors realized TPN and EN induced remission in crohn's disease patients. The data that dietary intervention through TPN and...
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