Crohn's Disease Forum » General IBD Discussion » Paratuberculosis Causes Crohn's

12-28-2014, 09:13 AM   #1
Critical Crohn's Meeting
Join Date: May 2014
Location: Montreal, Quebec
Paratuberculosis Causes Crohn's

M. Avium Paratuberculosis (MAP) causes Crohn's disease, PERIOD; We have two Crohn's children ONLY following an effective Anti MAP protocol and both have achieved full remissions. That says it all! Simple but highly virulent food poisoning causes CD:

Dig Liver Dis. 2002 Jan;34(1):29-38.
Treatment of severe Crohn's disease using antimycobacterial triple therapy--approaching a cure?
Borody TJ1, Leis S, Warren EF, Surace R.
Author information

Mycobacterium avium subspecies paratuberculosis is probably the best candidate for a microbial cause of Crohn's disease although arguments to the contrary can be equally convincing. Growing evidence suggests that prolonged antimycobacterial combination therapy can improve Crohn's disease in some patients.

To report long-term observations in patients with severe Crohn's disease treated with triple macrolide-based antimycobacterial therapy.

A series of 12 patients (7 male, 5 female; aged 15-42 years) with severe, obstructive or penetrating Crohn's disease were recruited.

Patients failing maximal therapy were commenced prospectively on a combination of rifabutin (450 mg/d), clarithromycin (750 mg/d) and clofazimine (2 mg/kg/d). Progress was monitored through colonoscopy, histology, clinical response and Harvey-Bradshaw activity index.

Follow-up data were available for up to 54 months of therapy Six out of 12 patients experienced a full response to the antiMycobacterium avium subspecies paratuberculosis combination achieving complete clinical, colonoscopic and histologic remission of Crohn's disease. Four of these patients were able to cease treatment after 24-46 months, 3 of whom remained in total remission without treatment for up to 26 months and one patient relapsed after six months off treatment. A partial response to the anti-Mycobacterium avium subspecies paratuberculosis combination was seen in 2 patients showing complete clinical remission with mild histologic inflammation. Return to normal of terminal ileal strictures occurred in 5 patients. Harvey-Bradshaw activity index in patients showing a full or partial response to therapy fell from an initial 13.4 +/- 1. 91 to 0. 5 +/- 0. 47 [n = 8, p < 0. 001) after 52-54 months.

Reversal of severe Crohn's disease has been achieved in 6/12 patients using prolonged combination anti-Mycobacterium avium subspecies paratuberculosis therapy alone. Three patients remain in long-term remission with no detectable Crohn's disease off all therapy These results support a causal role for Mycobacterium avium subspecies paratuberculosis in Crohn's disease while also suggesting that a cure may become possible.
Comment in

Treatment with drugs active against Mycobacterium avium subspecies paratuberculosis can heal Crohn's disease: more evidence for a neglected public health tragedy. [Dig Liver Dis. 2002]

[PubMed - indexed for MEDLINE]

Last edited by Jennifer; 12-29-2014 at 12:12 PM. Reason: Comment that deters treatment removed
12-28-2014, 02:51 PM   #2
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DustyKat's Avatar
Join Date: May 2010
Location: New South Wales, Australia
Thank you for your thoughts Critical Crohnís Meeting and it is very pleasing to hear that both of your children are remission.

However I do need to draw attention to your statement quoted below:

Don't listen to the jibberish of your gastroenterologist who is likely getting a kickback from big pharma to prescribe a cancer causing biologic drug like Remicade or Humira.
Perhaps you missed what is stated is the forum rules so I will post it here:

*Here on the forum we share facts with credible sources, personal experiences and offer support. Posts that deter a member from getting treatment suggested by their medical practitioner that they may need is not allowed. Such posts may be subject to editing and you will receive a warning.
As you have two children with Crohnís you would know how highly individual this disease is in itís presenting symptoms, location, phenotype and response. Whilst the study you have posted appears very promising it is small and dated and I note there was not a 100% successful outcome. That alone would suggest that not all sufferers of Crohnís are positive for MAP and/or are responsive to the treatment prescribed.

MAP and Anti-MAP therapy has been and continues to be discussed on the forum but again, at this point in time this is not a one size fits all disease.

I appreciate and understand your enthusiasm at finding an approach that works for your children and has you seeing them well and healthy but it is not our place to discourage the treatment paths sort by others, only they know what has occurred in getting to where they are.

Mum of 2 kids with Crohn's.
12-28-2014, 09:06 PM   #3
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FrozenGirl's Avatar
Join Date: Jan 2014

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Agreed. It is exciting but saying all GIs are just in it for kickbacks is unfair and untrue. In addition it was a very small study. Promising but not enough to say this 100 percent is the cause.
Dx: Ulcerative Colitis, Nov 2013
Currently on:
Mezavant 4.8g
Vitamin D 1000iu
Tecta 40mg
Remicade: 600mg, every 4 weeks
Methotrexate: 15 mg (injection)

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