04-18-2018, 03:38 PM   #931
wildbill_52280
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Join Date: Sep 2009
I was going to email Bill Gate's organization 4 years ago about funding microbiome studies. I never did but I'm glad to hear he is interested now!

https://www.bloomberg.com/news/artic...ine-technology

https://www.gatesnotes.com/Books/I-Contain-Multitudes
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04-28-2018, 02:44 PM   #932
wildbill_52280
Senior Member
 
Join Date: Sep 2009
Very large study on FMT in crohn's disease in china.

Brief Summary:
The gut microbiota is considered to constitute a "microbial organ" which has pivotal roles in the intestinal diseases and body's metabolism. Evidence from animal and human studies strongly supports the link between intestinal bacteria and inflammatory bowel diseases (IBD). Dozens of studies reported its efficacy in treatment of severe Clostridium difficile colitis. Preliminary studies using FMT for Ulcerative Colitis (UC), Crohn's diseases (CD), irritable bowel syndrome (IBS) and constipation have also met with some success. However, the results on CD is very limited. This is an initial step into investigating the potential efficacy of fecal bacteriotherapy for CD, the investigators propose to determine the efficiency, durability and safety of FMT in a series of 500 patients with CD in ten years.
04-28-2018, 03:18 PM   #933
artheta
 
Join Date: Jul 2011
Location: Aberdeen, United Kingdom
That sounds like news indeed, do you have a link to the study?
04-29-2018, 09:40 PM   #934
wildbill_52280
Senior Member
 
Join Date: Sep 2009
That sounds like news indeed, do you have a link to the study?
Yeah sorry here it is, they are recruiting patients, in China though. But I just noticed the same page says they are only enrolling 30 patients for this study,so there must be some mistake or something.
https://clinicaltrials.gov/ct2/show/NCT01793831
05-01-2018, 01:33 PM   #935
wildbill_52280
Senior Member
 
Join Date: Sep 2009
Fecal transplant shows promise in IBD, other chronic conditions

https://www.healio.com/gastroenterol...nic-conditions
05-05-2018, 07:59 PM   #936
hugh
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Fecal transplant shows promise in IBD, other chronic conditions

https://www.healio.com/gastroenterol...nic-conditions
holy crap.....
The 5 'D's of fecal transplants and not one of those 'd's is diet......
I'll wait till these clueless people work it out...

Compare that to Glenn Taylor of the Taymount (more than 20,000 FMTs),
from a podcast interview....

Getting a New Gut Microbiota via Fecal Transplant with Glenn Taylor
"GT: Let’s make sure everybody understands here. Bacteria are fussier eaters than teenagers. They like their substrate. They’re quite specific about what their enzymes that they produce can actually break down. So they live in an ordered structure.

They have an order in which bacteria, who make hundreds of times more enzymes than we humans can, when substrate food—what we’ve eaten—when substrate allies with them, species take it in turn to crack and break the molecule in the nutritional food substance down as they work their way through.

So a species will leap, and at the top, they’ll start. Other species will come in and say, “Hey, that’s stuff I can use.” They’ll break that. More species, and the whole thing cascades down.

And to make sure the entire food chain is fed, there’s such a structure that goes with it, which,......

And of course, the antibiotics kill bacteria by particular methodologies. And they kill the pathogenic (which their target species are) and similar styles of commensal. They’re killed by exactly the same mechanism.

So you’ve gone in to kill a pathogen. But at the same time, you’ve killed one of your native, commensal species. Now, if each one of those at a critical point in this digestive cascade as it goes from top to bottom is not there to break the food down further, who feeds the little guys below?.......

....... And I’m totally, totally with you on that one. The treatment package when you have your gut microbiota must include, first of all, understanding your own environment and make sure that you’re eating the right foods. At least you’ve got substrate anyway.......

But as you so accurately said, hormones play havoc with your gut bacteria if they start to respond in different strengths. So gut bacteria are affected by somebody’s emotional state, as you say, stress. Everything within in our environment remodels our gut micro flora. It’s very, very sensitive indeed.

And so, yes, it’s not just the last meal you had but the last row you had. And so we have to sit with patients and make sure they totally understand all of the ramifications of lifestyle. And that is every element of it."
https://drruscio.com/getting-new-gut...-glenn-taylor/
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Last edited by hugh; 05-05-2018 at 08:33 PM.
05-06-2018, 07:06 PM   #937
wildbill_52280
Senior Member
 
Join Date: Sep 2009
https://drruscio.com/getting-new-gut...-glenn-taylor/

I read some of this and I've become skeptical of glenn taylor from the taymount clinic. He brings up interesting topics but he doesn't sound educated enough to navigate the territory he is trying to navigate and coming from me, that's a bad sign, because even i don't claim to know it all, so that's why I doubt he does either.

It could be the case they are doing successful FMT's for various conditions, but why since 2009 have they not made any official attempt to document their success? It makes one wonder, but I would never get a FMT from the Taymount clinic at this point, nor would I recommend anyone do that.

The page did have an awesome link to a study I was looking for though! https://www.ncbi.nlm.nih.gov/pubmed/28105618
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