Yes, I have been on prednisone (was great for my Crohn's), was on Azathioprine (didn't seem to do much), Flagyl/Cipro (helped reduce abscess), and Humira (was great for my Crohn's and multiple severe fissures). Unfortunately, the day after I started Humira the abscess that led to my fissure started. To be fair, I had had in hindsight some very small abscess/fistula in that same location before a couple of years before but didn't know what it was and it healed by itself. I just thought it was a pimple gone crazy that healed itself. I had two years with no symptoms and the day after taking Humira a big welp appeared on my backside :-( I have read a lot of mixed information about Humira and abscesses/fistulas on the different forums, some saying they helped, some saying they made it worse. Eventually Humira didn't work for my Crohn's so I stopped it. By that time I was handling my Crohn's and healed quite well with an extremely strict diet and a ton of supplements. This is still what I am doing now. I agree that I need to get the inflammation response to change, I am looking into either trying to make the inflammation weaker so that it can heal, or even the opposite make inflammation more so that it kickstarts a new wave of healing in a way that wasn't activated before. I would really like to get this thing taken care of and am willing to go to extreme lengths, even having the surgery, I just want to exhaust some other reasonable options first. I find it really hard to believe with all the known drugs Western science has come up with and the traditions of medicine formed elsewhere under different cultures in the world that somewhere somebody has something that will make this go right away.
I have had two examples of this in my life. I had toe nail fungus for years and slowly watched as it spread from one toe to another toe and so on until my feet were so ugly. I went to doctor after doctor in America and bought lots of stuff (snake oil) on the internet. The only option the doctors gave me were nasty pills that had to be taken for a long time and often wouldn't work. Then once while traveling to South Korea, I stumbled my way into a pharmacy and thought I would ask them about it. Should what I had through a translator, without blinking an eye the pharmasist (looks just like a pharmacy in America) went to the back and got a little bottle of medical grade nail polish along with some nail filing sand paper things. I sanded the nails and put the nail polish on and did this regularly until the bottle was gone. The fungus went right away, it has been 6 years since and it didn't ever come back.
Another time I had really bad anal fissures for over 10 years. I don't need to tell you how excruciatingly painful this was to anybody who has these. I had three of them. Doctor after doctor would give my things that didn't do anything or helped only very little with bad side effects. One day during a winter day my lips around my mouth cracked and bled because they were so dry. I noticed the pain on the lips was a little bit similar but not nearly as intense as the fissures down below. I put the same chapstick (burt's bees original) down there out of desperation. (actually I had put many things down there out of desperation previously, so this wasn't a one off) and to my surprise they started to go away. After a couple of weeks they were gone. I remember sitting in my bathroom crying the first time I had a bm without blood in 10 years.
The problem with the chapstick was that if I ever stopped using it, they would just come back. Eventually once my Crohn's was under control I got rid of them entirely. This only happened after taking Humira, diet, and supplements. It has been over a year since I had to use chapstick. I know that sounds crazy, and I am not saying that it will work for anybody else, but the point is with me and my test case of one, it worked really well.
I refuse to accept that there isn't something I can just put down there and it facilitates the healing, every doctor I have been too told me it can only be healed with surgery, but I heard the same thing about my toenail fungus and fissures too. On top of that, my doctors told me that diet doesn't play a role in Crohn's when in fact for me it is the #1 factor. If I stay on my diet, I don't have any apparent and painful problems, but I got off the bite even a crumb and I feel it for sure. So the point is, I believe there are ways to get better and I will invest lots of money, time, and effort to find them.