04-18-2018, 03:38 PM   #931
wildbill_52280
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I was going to email Bill Gate's organization 4 years ago about funding microbiome studies. I never did but I'm glad to hear he is interested now!

https://www.bloomberg.com/news/artic...ine-technology

https://www.gatesnotes.com/Books/I-Contain-Multitudes
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04-28-2018, 02:44 PM   #932
wildbill_52280
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Very large study on FMT in crohn's disease in china.

Brief Summary:
The gut microbiota is considered to constitute a "microbial organ" which has pivotal roles in the intestinal diseases and body's metabolism. Evidence from animal and human studies strongly supports the link between intestinal bacteria and inflammatory bowel diseases (IBD). Dozens of studies reported its efficacy in treatment of severe Clostridium difficile colitis. Preliminary studies using FMT for Ulcerative Colitis (UC), Crohn's diseases (CD), irritable bowel syndrome (IBS) and constipation have also met with some success. However, the results on CD is very limited. This is an initial step into investigating the potential efficacy of fecal bacteriotherapy for CD, the investigators propose to determine the efficiency, durability and safety of FMT in a series of 500 patients with CD in ten years.
04-28-2018, 03:18 PM   #933
artheta
 
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Location: Aberdeen, United Kingdom
That sounds like news indeed, do you have a link to the study?
04-29-2018, 09:40 PM   #934
wildbill_52280
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That sounds like news indeed, do you have a link to the study?
Yeah sorry here it is, they are recruiting patients, in China though. But I just noticed the same page says they are only enrolling 30 patients for this study,so there must be some mistake or something.
https://clinicaltrials.gov/ct2/show/NCT01793831
05-01-2018, 01:33 PM   #935
wildbill_52280
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Fecal transplant shows promise in IBD, other chronic conditions

https://www.healio.com/gastroenterol...nic-conditions
05-05-2018, 07:59 PM   #936
hugh
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Fecal transplant shows promise in IBD, other chronic conditions

https://www.healio.com/gastroenterol...nic-conditions
holy crap.....
The 5 'D's of fecal transplants and not one of those 'd's is diet......
I'll wait till these clueless people work it out...

Compare that to Glenn Taylor of the Taymount (more than 20,000 FMTs),
from a podcast interview....

Getting a New Gut Microbiota via Fecal Transplant with Glenn Taylor
"GT: Let’s make sure everybody understands here. Bacteria are fussier eaters than teenagers. They like their substrate. They’re quite specific about what their enzymes that they produce can actually break down. So they live in an ordered structure.

They have an order in which bacteria, who make hundreds of times more enzymes than we humans can, when substrate food—what we’ve eaten—when substrate allies with them, species take it in turn to crack and break the molecule in the nutritional food substance down as they work their way through.

So a species will leap, and at the top, they’ll start. Other species will come in and say, “Hey, that’s stuff I can use.” They’ll break that. More species, and the whole thing cascades down.

And to make sure the entire food chain is fed, there’s such a structure that goes with it, which,......

And of course, the antibiotics kill bacteria by particular methodologies. And they kill the pathogenic (which their target species are) and similar styles of commensal. They’re killed by exactly the same mechanism.

So you’ve gone in to kill a pathogen. But at the same time, you’ve killed one of your native, commensal species. Now, if each one of those at a critical point in this digestive cascade as it goes from top to bottom is not there to break the food down further, who feeds the little guys below?.......

....... And I’m totally, totally with you on that one. The treatment package when you have your gut microbiota must include, first of all, understanding your own environment and make sure that you’re eating the right foods. At least you’ve got substrate anyway.......

But as you so accurately said, hormones play havoc with your gut bacteria if they start to respond in different strengths. So gut bacteria are affected by somebody’s emotional state, as you say, stress. Everything within in our environment remodels our gut micro flora. It’s very, very sensitive indeed.

And so, yes, it’s not just the last meal you had but the last row you had. And so we have to sit with patients and make sure they totally understand all of the ramifications of lifestyle. And that is every element of it."
https://drruscio.com/getting-new-gut...-glenn-taylor/
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Last edited by hugh; 05-05-2018 at 08:33 PM.
05-06-2018, 07:06 PM   #937
wildbill_52280
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https://drruscio.com/getting-new-gut...-glenn-taylor/

I read some of this and I've become skeptical of glenn taylor from the taymount clinic. He brings up interesting topics but he doesn't sound educated enough to navigate the territory he is trying to navigate and coming from me, that's a bad sign, because even i don't claim to know it all, so that's why I doubt he does either.

It could be the case they are doing successful FMT's for various conditions, but why since 2009 have they not made any official attempt to document their success? It makes one wonder, but I would never get a FMT from the Taymount clinic at this point, nor would I recommend anyone do that.

The page did have an awesome link to a study I was looking for though! https://www.ncbi.nlm.nih.gov/pubmed/28105618
06-04-2018, 06:21 PM   #938
wildbill_52280
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https://hai.stanford.edu/events/eran...th-and-disease
06-04-2018, 08:37 PM   #939
wildbill_52280
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Gastroenterol Res Pract. 2018 Apr 3;2018

The Value of Fecal Microbiota Transplantation in the Treatment of Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis.

Abstract
BACKGROUND AND AIMS:
Fecal microbiota transplantation (FMT) has challenged the traditional management of ulcerative colitis (UC) in recent years, while it remained controversial. We aimed to provide a systematic protocol of FMT treatment on UC.

METHODS:
Studies reporting on FMT treatment in UC patients were performed. A fixed-effect model was used to assess the efficacy of FMT.

RESULTS:
Eighteen studies were enrolled (n = 446). A pooled proportion of patients who received FMT had a significant efficacy compared to the placebo group (odds ratio (OR): 2.73, P = 0.002) with a low risk of heterogeneity (P = 0.59, I2 = 0%). The Mayo score decreased to 5 points in a state of mild-moderate activity after FMT treatment, and the optimal range of the Mayo score baseline was 6-9 for FMT administration. Then, the baseline of the Shannon diversity index (SDI) had a negative correlation with the clinical response rate (R = -0.992, P = 0.08) or remission rate (R = -0.998, P = 0.036), and the optimal diversity of bacteria was at 7 days to one month. Moreover, the colonoscopy delivery and unrelated fecal donor had slight superiorities of FMT treatment.

CONCLUSION:
FMT treatment had a higher efficacy and shorter time-point of early assessment of effectiveness on UC patients compared to traditional therapies. And the optimal FMT delivery and donor were colonoscopy delivery and unrelated donor in clinical practice.


https://www.ncbi.nlm.nih.gov/pubmed/29849592
06-05-2018, 03:49 PM   #940
wildbill_52280
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Fecal microbiota transplantation improved symptoms in patients with refractory irritable bowel syndrome with severe abdominal bloating. Among 22 responders who were contacted at 1 year, six (27%) reported long-lasting effects, and five of them were from the FMT group.

https://www.healio.com/gastroenterol...minal-bloating
06-13-2018, 01:32 PM   #941
wildbill_52280
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Most protocols processing of stool for FMT destroy the bacteria that are needed due to exposure to oxygen. Finally someone is addressing this issue, I've known about this possibility for years now though. For DIY, using a blender to mix stool with saline will likely expose a lot of oxygen to it, mixing it slowly in a freezer bag that has no air might help protect it.

https://www.healio.com/infectious-di...educe-efficacy
06-18-2018, 10:23 PM   #942
wildbill_52280
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more than 150 drug makers globally are working on potential medicines for various disorders that could be linked to the human microbiome, and they have invested more than $2 billion in research, said Mo Langhi, an organizer of this week’s microbiome conference.
It sounds like a preposterous idea: Collect a sample of every type of bacteria that lives in the human gut. But that’s the goal of Bernat Olle, an MIT-trained chemical engineer. Over the past three years, the Cambridge biotech startup he runs, Vedanta Biosciences Inc., has assembled a menagerie of some 60,000 bacteria types.
https://www.bostonglobe.com/business...IyH/story.html
08-01-2018, 10:39 PM   #943
wildbill_52280
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WebMD health news: Research Flourishes on Promise of Fecal Transplants, Aug. 1, 2018.

Madelynn Hernandez was in a battle. The California teenager loved to draw, dance, and study math, but her Crohn’s disease was seriously getting in the way.

“I had so much nausea, and my head was often spinning,” she says. “Sometimes I had good days and I was fine, but on the bad days, I just wanted to stay at home and lie on the couch. I was missing a lot of school.”

So last fall, when her doctor talked to her about being part of a study of new treatments for young people with bowel diseases, Hernandez jumped at the chance, even if it meant having someone else’s fecal matter put inside her body.


Since receiving her fecal transplant, Hernandez’s Crohn’s disease remains in remission, and she has stopped taking most of her medications. In the next few months, the now 16-year-old expects to eliminate all of them.

“I feel so much better,” Hernandez says. “No stomach pain, no diarrhea.”
https://www.webmd.com/digestive-diso...al-transplants

Last edited by wildbill_52280; 08-02-2018 at 03:55 PM.
10-01-2018, 02:46 PM   #944
wildbill_52280
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Two studies characterize the transmission of the microbiome from mother to infant during the first months of life. October 1, 2018 | Andreu Prados

the maternal gut microbiome provided the largest contribution of transmitted strains. It was also found that maternal gut strains were more likely to adapt and persist in the infant gut compared with those acquired from other sources.
http://www.gutmicrobiotaforhealth.co...onths-of-life/
10-02-2018, 02:29 PM   #945
wildbill_52280
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Bringing order to the ‘wild frontier’ of microbiome medicine.
By BERNAT OLLE, OCTOBER 2, 2018
https://www.statnews.com/2018/10/02/...-living-drugs/

Several startups and large pharmaceutical companies are doing important work to advance microbiome-related treatments.

But there are still many questions, as the FDA workshop made clear. Here are three big ones: How can we ensure that the bacteria included in living drugs won’t contribute to the spread of antibiotic resistance or virulence genes? What are the appropriate assays to ensure the quality of a living drug that will be used in clinical studies and, hopefully, in treatments? Can we ensure the manufacturing process will create consistent products? The industry must answer these correctly before the FDA will approve living drugs.
Fecal transplants, which are inherently variable mixtures of undefined microbial composition, are no longer the only way to deliver health-promoting microbes to people who need them. Advances in basic science are positioning researchers to use more rigorous and systematic approaches to harnessing the power of the microbiome.

The company I lead, Vedanta Biosciences in Cambridge, Mass., and others are working to develop drugs that consist of carefully defined consortia of bacteria that have been shown to work together to fight off pathogens or to stimulate immune responses via the gut.

There will likely be many approaches to doing this. At Vedanta, we select strains of bacteria to include into possible drugs from a collection of tens of thousands of pure single-strain cultures. Once we have identified the strains we believe will work best together, we grow them separately in growth chambers called fermentors — no fecal donations needed. After extracting the bacteria from their fermentors, we freeze-dry them into stable powders, mix the powdered strains together, and pack the mixture into capsules.

Swallowing such a capsule releases the assemblage of helpful bacteria into the gut, where they are awakened from hibernation. As they colonize the gut and begin fitting in with the existing microbial ecosystem, they can help remodel the patient’s microbiome, creating a more resilient ecosystem better able to fight infections. The right mixtures can also manipulate the immune system in the intestine, either to tone it down (to help those with inflammatory bowel diseases or food allergies) or to rev it up (to help potentiate cancer immunotherapies and vaccines).
10-20-2018, 03:08 PM   #946
OleJ
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Hi Wildbill.
I frequently stop by this thread to see what news you have found and relay to us. Te latest research projects conclusions seem promising for the wider acceptance of this treatment option.
Fantastic to ve able to hope options outside immunosuppression.
y GI still refuses FMT has a place in the treatment of IBD but I am warming to the possibility of the DIY approach. Is just that the possibe donors don't do well on the Bristol scale
But I digress..

What I really wanted though is to extend a warm thank you to you for gathering the relevant research here.
so thank you!
10-21-2018, 07:28 PM   #947
william4
 
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Location: long island ny
I look forward to your posts wildbill
11-15-2018, 02:35 PM   #948
wildbill_52280
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Human transition from hunter gathers to Agriculture is linked to changes in the microbiome.

"the Tharu, the Raute, the Raji and the Chepang -- are longtime residents of the Himalayan foothills, with similar languages, cultural practices and ancestry. Where the four diverge is in their dietary history: The Tharu have practiced agriculture for the past 250 to 300 years; the Raute and the Raji have practiced agriculture for the past 30 to 40 years; and the Chepang are hunter-gatherers. The study found that the composition of the gut microorganisms, or gut microbiome, of each population differed based on whether and how long ago it had departed from a hunter-gatherer lifestyle."
https://www.eurekalert.org/pub_relea...-vig110918.php

Last edited by wildbill_52280; 11-15-2018 at 09:17 PM.
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