Crohn's Disease Forum » Treatment » Bacteriotherapy or fecal transplantation


10-19-2010, 12:26 PM   #1
Igor_Passau
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Bacteriotherapy or fecal transplantation

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Dr. Khoruts decided his patient needed a transplant. But he didn’t give her a piece of someone else’s intestines, or a stomach, or any other organ. Instead, he gave her some of her husband’s bacteria.

Dr. Khoruts mixed a small sample of her husband’s stool with saline solution and delivered it into her colon. Writing in the Journal of Clinical Gastroenterology last month, Dr. Khoruts and his colleagues reported that her diarrhea vanished in a day. Her Clostridium difficile infection disappeared as well and has not returned since.

The procedure — known as bacteriotherapy or fecal transplantation — had been carried out a few times over the past few decades. But Dr. Khoruts and his colleagues were able to do something previous doctors could not: they took a genetic survey of the bacteria in her intestines before and after the transplant.

Before the transplant, they found, her gut flora was in a desperate state. “The normal bacteria just didn’t exist in her,” said Dr. Khoruts. “She was colonized by all sorts of misfits.”

Two weeks after the transplant, the scientists analyzed the microbes again. Her husband’s microbes had taken over. “That community was able to function and cure her disease in a matter of days,” said Janet Jansson, a microbial ecologist at Lawrence Berkeley National Laboratory and a co-author of the paper. “I didn’t expect it to work. The project blew me away.”

Scientists are regularly blown away by the complexity, power, and sheer number of microbes that live in our bodies. “We have over 10 times more microbes than human cells in our bodies,” said George Weinstock of Washington University in St. Louis. But the microbiome, as it’s known, remains mostly a mystery. “It’s as if we have these other organs, and yet these are parts of our bodies we know nothing about.”

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full artikle ww.nytimes.com/2010/07/13/science/13micro.html?pagewanted=1&_r=3
10-29-2010, 06:05 AM   #2
Igor_Passau
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Fecal bacteriotherapy, also known as fecal transfusion, fecal transplant, or human probiotic infusion (HPI), is a medical treatment for patients with pseudomembranous colitis (caused by Clostridium difficile), or ulcerative colitis which involves restoration of colon homeostasis by reintroducing normal bacterial flora from stool obtained from a healthy donor

The procedure has been used to successfully cure C. difficile infections for a number of years, with a success rate of nearly 95% according to some sources[7][8][9]. The benefits of fecal bacteriotherapy include reducing the risk of antibiotic-associated resistance, cost savings when compared to repeated courses of antibiotic therapy, and high success rate. It is still considered a "last resort" therapy due to the inherent risks involved and lack of Medicare coverage for donor stool screening and instillation procedure.[1]
While its effects on ulcerative colitis have not yet been adequately researched, small case series suggest it has positive effects. A recent article by Borody et al. which details 6 cases of severe chronic ulcerative colitis treated using Fecal bacteriotherapy suggests that the procedure may be extremely successful in these cases as well. Complete reversal of symptoms was achieved in all patients by 4 months post-HPI, by which time all other UC medications had been ceased. At 1 to 13 years post-HPI and without any UC medication, there was no clinical, colonoscopic, or histologic evidence of UC in any patient[10]. The Sydney group also reports a case of presumed sclerosing cholangitis, a disease frequently associated with IBD, which recovered fully after the treatment.

_ttp://en.wikipedia.org/wiki/Fecal_bacteriotherapy
10-29-2010, 06:07 AM   #3
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Fecal bacteriotherapy and UC.


_ww.sydneybrandingservices.com.au/CDD/pdf/publications/paper17.pdf
10-29-2010, 06:10 AM   #4
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Reserch centers:

_ww.duluthclinic.org/specialtycenters/digestivehealth/stooltransplant.htm
_ww.probiotictherapy.com.au/pages/what_is_hpi.html
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