Crohn's Disease Forum » Treatment » Humira/Adalimumab » Timing of my 1st Humira loading dose...


04-15-2019, 12:06 PM   #1
Rose09
 
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Timing of my 1st Humira loading dose...

Hello everyone, newbie to the forum !
I have finally agreed to Humira for Crohn's Colitis....currently on Lialda. This is my first biologic.

What would your advice be re: the days following the first few shots ? Days off work if i can ? (I am a nurse in urgent care so lots of infection risk...mask worn and frenzied hand washing !)

I have read that fatigue following doses is common ?
I know its every 2 weeks...have any of you been late with that by 1 day ? thinking of travel etc.

Thanks so much, It's all been overwhelming...i'm so glad to have found this forum !
04-17-2019, 03:18 AM   #2
positive_skeptic
 
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When I was on Humira, my loading dose consisted of 8 shots in one day. Then my regular dosing was going to be one shot every two weeks. And I didn't miss a day
04-17-2019, 04:54 PM   #3
Rose09
 
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thank you for your reply, did you have any after effects following the loading dose ?
04-17-2019, 05:56 PM   #4
my little penguin
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Ds used to get wiped out the day after
Especially in the beginning
No skipping doses
In the US they ship it to the local pharmacy Ups or where your staying if need be
You can carry it in a cooler
And it can stay at room temp up to 14 days but must be used before the 14 day mark once it’s allowed to warm up

We always used a cooler
Good luck
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04-17-2019, 06:02 PM   #5
Rose09
 
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I am expecting to be wiped out too...
Walgreens are shipping it to me Friday, I will be at home to put it straight in the fridge. The plan is to start next friday but I could bring it forward if I want to . I am just so nervous about starting, I know I am putting it off because I am having zero symptoms and perfect BMs

Last edited by Rose09; 04-17-2019 at 06:06 PM. Reason: added info
04-17-2019, 06:55 PM   #6
Scipio
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I am just so nervous about starting, I know I am putting it off because I am having zero symptoms and perfect BMs
I know how you feel. I put off starting a biologic (Stelara in my case) for several years because I had only minimal symptoms - occasional mild right side abdominal pain and no diarrhea.

But reality suddenly caught up with me when the Crohn's hit me hard with an extra-intestinal manifestation of acute pericarditis, and I found myself undergoing major open-chest surgery to fix that. I've been on Stelara ever since.
04-17-2019, 07:27 PM   #7
Rose09
 
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wow that sounds very scary, I had no idea Crohn's could manifest as pericarditis....I hope you are doing well on the Stelara. My uncle is on that for Crohn's and is doing well so far (he has been on everything else and had surgery in the past).
04-18-2019, 07:55 AM   #8
positive_skeptic
 
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thank you for your reply, did you have any after effects following the loading dose ?
I have never had any bruising or reactions. It just stings a little
04-18-2019, 10:19 AM   #9
Scipio
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wow that sounds very scary, I had no idea Crohn's could manifest as pericarditis
I didn't either. It's pretty rare but not unheard of. There are some reports of it in the medical literature. Pericarditis is a fairly common complication of lupus, which made the docs think I might also have lupus. But after a lot of testing they decided I didn't have lupus and the pericarditis came from the Crohn's.

And I'm doing very well on the Stelara. It's just one shot every 8 weeks (after the loading dose infusion), and I'm having no symptoms at all and my latest colonoscopy and regular blood work all look great. I just hope it keeps working.
04-18-2019, 12:34 PM   #10
Rose09
 
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Stelara sounds really positive, I wonder why my dr didn't choose that one...
I like the idea of one shot every 8 weeks instead of 2.
I'm very impressed that you have good results in your scope and labs, especially after what you have been through, that's awesome!
04-18-2019, 05:46 PM   #11
my little penguin
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Possible reasons why
Most insurance require you to do step up therapy before they cover a drug
This means failing humira and or remicade
Prior to trying the more expensive biologics

Humira is much cheaper than stelara
Humira works quickly 3-4 months

Stelara takes 6-12 months to work

Stelara works for some crohns but not others
Humira has more years of experience with crohns

Good luck
Yesterday, 04:33 PM   #12
Lady Organic
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Started Humira a couple of months ago and very happy. No side effect at all. Hopefully you react well too
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''UC-like Crohn's'' (2001)
wrists + ankles arthropathies (2013)
on: Humira
Diet: ''IBD-AID'' : http://www.nutritionj.com/content/13/1/5+ organic food only, Vitamin D + B12 shots
Past meds: prednisone 50mg, 5-ASA (pill, rectal), cortifoam, cortenema, Imuran, Purinethol, methotrexate.
Yesterday, 08:53 PM   #13
Rose09
 
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Lady Organic thank you! another great story with no side effects ... helps me continue to feel more positive.
Can I ask, were you having symptoms at the time you started Humira ?
Yesterday, 08:59 PM   #14
Rose09
 
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Join Date: Feb 2019
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Possible reasons why
Most insurance require you to do step up therapy before they cover a drug
This means failing humira and or remicade
Prior to trying the more expensive biologics

Humira is much cheaper than stelara
Humira works quickly 3-4 months

Stelara takes 6-12 months to work

Stelara works for some crohns but not others
Humira has more years of experience with crohns

Good luck
I never knew that Humira was cheaper than Stelara...makes sense now. Stelara has less side effects from what I have read. At least there are options if Humira fails.
Today, 09:16 AM   #15
Lady Organic
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In my rectum only. Moderate disease activity. The positive reaction to treatment was spectacular in my case, really fast!
Today, 12:20 PM   #16
Rose09
 
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Lady Organic, thank you, good to hear that you had a fast result!
For me, I am doing well since my recent awful flare in Jan/Feb. Because I don't have symptoms at the moment I will have to wait to measure the success of Humira when I get another scope in the future ..or the absence of any flares in the next year of course.
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