Crohn's Disease Forum » Books, Multimedia, Research & News » MAP Vaccine Ready for Human Trials - Could be Used for Crohn's


 
03-30-2014, 06:14 AM   #181
tzvia
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how do you sign up for this trial?
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03-30-2014, 06:35 AM   #182
sir.clausin
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You don't
03-30-2014, 06:36 AM   #183
tzvia
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then what do you do? is this a drug trial?
03-30-2014, 06:41 AM   #184
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Its too early dear, first we need to set up the foundation for the charitywork. If you are interested in helping out, let me know.
03-30-2014, 01:20 PM   #185
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At this point tzvia, they are looking to raise more funds in order to start human trials. They have no government funding and are relying on the people, charities etc to help raise enough money for it to go to human trials. If you check out the first post of this thread on page #1, you'll see an attachment that shows you how you can donate if you choose to do so (the attachment also talks about MAP and gives more information about the vaccine). They are working on getting an easier way to donate online that won't go through a 3rd party so all the donations can go directly to the cause and not let someone else get a cut of the money (the attachment on the first page goes directly to the cause yet you have to send in a check). Once that link is ready then I'll post it in this thread and edit it into the first post.
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Diagnosis: Crohn's in 1991 at age 9
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Things I take: Tenormin 25mg (PVCs and Tachycardia), Junel (endometriosis), Tylenol 3 (Osteoarthritis), Zantac 150mg 2/day (acid reflux), Klonopin 1mg (Panic Disorder), Imitrex 25mg (migraines), Zofran 8mg (nausea)
Currently in: REMISSION Thought it was a flare but it's just scar tissue from my resection. Dealing with a stricture. Remission from my resection, 19 years and counting.
03-30-2014, 03:11 PM   #186
tzvia
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oh, I see
04-22-2014, 07:06 PM   #187
AJC - Australia
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their facebook page is now asking ,

Is there someone in your life that has helped you through the low points of your life with Crohn's Disease? If there is, can you please write a few sentences (in the comments below) to say how important that person/s is/was to you and perhaps a little about how they helped you...we will add your quote to our 'MY HERO' collage that we are compiling.

If you have a photo of you with your hero, please email it to us [email protected] and we will add your quote to the photo and to the collage. We look forward to sharing the collage with you in coming weeks.
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I believe this could cure crohns disease.

-Dr John Hermon -Taylor is trying to cure Crohn's disease.
04-24-2014, 01:26 PM   #188
Leopardos
 
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Hello everyone,

I'm excited about this research which could lead to chrohn cure...
I just saw an old videos on YouTube, Prof. explaining about the MAP Vaccine, its 6 years old,
Is it gonna take long? Could we see a Cure for Crohn in 1 year or 2 ? :/
04-24-2014, 01:28 PM   #189
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Hello everyone,

I'm excited about this research which could lead to chrohn cure...
I just saw an old videos on YouTube, Prof. explaining about the MAP Vaccine, its 6 years old,
Is it gonna take long? Could we see a Cure for Crohn in 1 year or 2 ? :/
From their fcebook page

"If full funding were in place, we would be looking at completing GMP (Good Manufacturing Practice) manufacture by the end of 2015. So the earliest the vaccine could be made available to patients would be mid 2016."

Unfortunately, full funding isnt in place.. at all. So even if the vaccine ends up working, it's a long way away.
04-24-2014, 01:36 PM   #190
xmdmom
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Well in the scheme of things 2 years is not very long. Yes we all would like it now but 2 years will be here sooner than you know.
04-24-2014, 01:51 PM   #191
JMC
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Stephen Sutton raised £1.9M for a cancer charity in 24 hours because he had terminal bowel cancer. 5M Crohns sufferers can raise the £4M needed quickly if necessary. Just believe.

04-26-2014, 12:05 AM   #192
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Interesting information about the MAP test (check the full reply on their fb site):

" FAQ #7: Can I get tested for MAP?

MAP testing is not available through hospital clinics -it is currently only done in research laboratories. No tests for MAP are yet 'clinically validated' although with the modern methods used they are highly accurate and sensitive. This is the case worldwide, not just in the UK. Currently, specialists who treat Crohn’s with anti-MAP antibiotics usually do so without testing for MAP, in the knowledge that the vast majority of Crohn’s patients will test positive.

Prof. Hermon-Taylor is completing the development of a new diagnostic test for MAP. This is a smart, simple test which can be done on a blood or tissue sample. It will ultimately be automatable -so that hundreds of tests can be done very quickly, using standard equipment already available to hospital labs across the world...."
04-26-2014, 03:32 AM   #193
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Interesting article on MAP here although written in 2001:

http://www.mad-cow.org/00/paraTB.html
04-26-2014, 05:37 PM   #194
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It was very interesting - and long! What can we do? I brought this to the attention of our daughter's GI and she just pushed it aside.
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04-27-2014, 08:39 AM   #195
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I think the problem is that this has been going on for so long - at least 25 years - that a lot of Gi's have come to the conclusion, rightly or wrongly, that if there was anything in it it would have been found by now.
04-27-2014, 08:57 AM   #196
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GI are doctors. People looking at the zoonotic potential of MAP are biologists and biomedical engineer. It is in our benefit that GI don't get involved in this discussion, nor should they be.
04-27-2014, 10:02 AM   #197
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Remember that Dr. Crohn himself thought MAP was a probable cause or trigger for the disease that now bears his name! But MAP is very, very difficult to culture. I don't think it was possible until modern DNA testing reached a certain level.
04-27-2014, 01:21 PM   #198
JMC
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I think the problem is that this has been going on for so long - at least 25 years - that a lot of Gi's have come to the conclusion, rightly or wrongly, that if there was anything in it it would have been found by now.
It is true that the research has been going on for a long time, but during that time there has been slow steady progress against a back drop of very limited research funding. On a small scale, Crohn's patients have been tested for MAP infection (92% were positive) and of those, many achieved remission with a combination of antibiotics that target MAP. There is an argument over whether this is significant or not, but it persists mostly due to an absence of effective, large scale, clinical trials which could prove conclusively either way.

During the last twenty years the main issues faced have been:
1) It has been very difficult to test for MAP in blood and tissue samples
2) If the infection is cleared with antibiotics there is a high risk of re-infection
3) Producing a treatment that can permanently clear the body of MAP infection has been difficult

Recently, there has been significant progress on all counts, including new diagnostic tests for MAP, an extensive antibiotic trial and the development of an anti-MAP vaccine.

Although some gastros may dispute that MAP is the cause of Crohns, what they certainly cannot tell you is:
1) You are not infected with MAP because they do not have easy access to testing
2) If you were infected with MAP it would not cause any issues

Last edited by JMC; 04-28-2014 at 07:12 AM.
04-30-2014, 01:34 PM   #199
Malgrave
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Latest update on the Fb site:

Prof. Hermon-Taylor and his team have developed a modern DNA vaccine against MAP. This took 10 years and cost around £850,000, much of it donated by Crohn’s families, without whom this promising new vaccine would not exist. The key features of the Vaccine are:

(1) Treatment: Modern vaccines can be used to treat, as well as prevent, established chronic infectious diseases. If the vaccine works as well in humans as it does in cattle then there is every chance that it could CURE, or significantly attenuate, Crohn’s Disease

(2) Prevention: The vaccine could be given to those at higher risk of developing Crohn’s Disease (e.g. children of those with Crohn’s) to prevent them from ever getting the disease. It could also be given to domestic livestock to prevent MAP getting into the food chain in the first place. Although this would not eradicate exposure completely (MAP still exists within the environment) it would dramatically reduce human exposure.

(3) Mechanism of action: The vaccine is what is called a ‘T-cell’ vaccine. T-cells are a type of white blood cell -an important player in the immune system- in particular for fighting against organisms that hide INSIDE the body’s cells –like MAP does. Many people are exposed to MAP but most don’t get Crohn’s –Why? Because their T-cells can ‘see’ and destroy MAP. In those who do get Crohn’s, the immune system has a ‘blind spot’ –their T-cells cannot see MAP. The vaccine works by UN-BLINDING the immune system; stimulating the body’s T-cells to seek out and destroy cells containing MAP.

(4) Efficacy: In extensive tests in animals (in mice and in cattle), 2 shots of the vaccine proved to be a powerful, long-lasting stimulant of immunity against MAP. See below if you would like to read the published data from the trial in mice. The results from the trial of the vaccine in cattle are currently being prepared for publication... but we have already seen and analysed the data and they demonstrate even more strongly how effective the vaccine is.

(5) Safety: There were no obvious adverse effects from the vaccine in either of the animal trials. Obviously the vaccine still needs to be tested in humans... but because it is highly specific, targeting only MAP-containing cells, we would predict that the safety profile in humans is likely to be very similar to that in animals.

We need to get this Vaccine manufactured and into clinical trials!

http://www.plosone.org/article/info%...l.pone.0001229
05-02-2014, 11:01 AM   #200
Malgrave
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Interesting studies:

http://www.plosone.org/article/info%...l.pone.0062780

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975476/

http://informahealthcare.com/doi/abs...21.2013.857713

http://www.ncbi.nlm.nih.gov/pubmed/24522266

Last edited by Malgrave; 05-02-2014 at 01:24 PM.
05-08-2014, 02:39 AM   #201
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http://www.medscape.com/viewarticle/752223_1

I have just been reading this article which I believe may be of interest to everyone here. It's a mouthful, but it collates some very strong supporting evidence for a MAP targeted treatment, and comparison to some of the leading treatments currently available.

Note: The article is based on antibiotic treatment specifically, but does have some information on the nature and potential benefit of Anti-MAP treatment.
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05-08-2014, 07:09 AM   #202
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I couldn't read the article because I don't have a Medscape account. Would you mind telling us the article's title? Sometimes I can find medical articles other places by searching for the title.
05-08-2014, 08:53 AM   #203
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DOES ANYBODY HAVE TWITTER!!!! I do not, but DYNAMO the famous magician suffers badly from Crohn's Disease... someone could direct him to this EXACT THREAD and he might be able to at least raise the profile of the research.
05-08-2014, 09:00 AM   #204
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GI are doctors. People looking at the zoonotic potential of MAP are biologists and biomedical engineer. It is in our benefit that GI don't get involved in this discussion, nor should they be.
That said, the reason MAP research never really took off (with the exception of JHT and Borody) is because GI's didn't accept MAP as a causative factor. They didn't accept it previously because there was no accurate diagnostic test before.
05-08-2014, 01:53 PM   #205
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DOES ANYBODY HAVE TWITTER!!!! I do not, but DYNAMO the famous magician suffers badly from Crohn's Disease... someone could direct him to this EXACT THREAD and he might be able to at least raise the profile of the research.
Yes, I have already tweeted him about this. I will try again once the MAP Vaccine website is up.

05-16-2014, 06:42 AM   #206
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I couldn't read the article because I don't have a Medscape account. Would you mind telling us the article's title? Sometimes I can find medical articles other places by searching for the title.
My apologies, I keep forgetting that I'm signed into my Uni library account (and thus have access to databases)

The name of the paper is:

Chamberlin, W. Borody, T.J. Campbell, J. 2011 'Primary treatment of Crohn's disease: combined antibiotics taking center stage' Expert Rev. Clinical Immunology. Vol 7(6), pp 751-760


EDIT: Thank you HelenMelb!

Last edited by zilla7777; 05-16-2014 at 07:13 AM.
05-18-2014, 11:43 AM   #208
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A problem I think with this antibiotic strategy is something other people have pointed out too. If it is given indiscriminately without knowing if the patient harbours MAP but instead harbours other pathogens like invasive E Coli, you are going to create resistance against gram- bacteria, which could make antibiotics that are effective against E Coli like cipro less effective. Antibiotic resistance is a major issue if you want to target AIEC. In a lot of people with crohn's disease, especially people with ileum involvement, you can detect AIEC but not MAP, the case for AIEC is quite a bit stronger than it is for MAP, so they need to be absolutely sure those people have MAP, which I don't think happened in that study.

I said on the other page I strongly doubt that everyone with crohn's disease has MAP, there are studies that show MAP in crohn's disease people, but I know a lot of unpublished accounts of people where they found no MAP in big numbers of people. They're not published since the DNA test was done by labs that aren't supposed to do the test on humans, so it's never published. Lots of veterinary labs can do IS900 test for MAP DNA and culture, just because they're not supposed to test humans doens't mean it doesn't happen, if you want to get tested you can if you insist, the equipment and tests are there and this is an issue the farming industry is interested in too. If they use antibiotics indiscriminately, they are going to do more harm than good.

Last edited by kiny; 05-18-2014 at 12:09 PM.
05-18-2014, 04:20 PM   #209
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I agree that taking anti biotics forever more does not seem like a viable option, especially as the gastro world (of specialists) are leaning towards the gut ecology being of utmost importance in their current studies/theories for better health in CD.
Prof Hermon-Taylor's MAP vaccine begins with the MAP diagnostic test. There are a few doctors, research labs currently developing a modern diagnostic that will accurately be able to show you if you do/dont have a MAP infection. This is exciting! It would be so huge for everyone if they could test 10, 000 CD patients next week.

Until that MAP diagnostic test is available, we are all playing the waiting game.
05-18-2014, 06:58 PM   #210
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If the gut flora is relevant will be an endless debate until they find the cause I think. The studies that are quoted a lot are the ones that show that you need a fecal stream and microbiome to induce collitis in some animals and if you do fecal diversion in CD patients, that specific area seems to heal up on it's own. But collitis in animals is not the same as Crohn's disease, collitis in mice is done with DSS that they give to the mice until they get collitis. The most accurate mouse model of crohn's disease is not one that involves the gut flora, or DSS, or fecal stream, it's the one where they infected the mouse with AIEC, an intracellular pathogen. I will doubt the gut flora is involved until there is actual proof there is, I don't see much proof just the fact there is dysbiosis, dysbiosis happens in many diseases.

The intestine is full of macrophages, if anything is going to exploit the innate immunodeficiencies in crohn's disease it's going to be a pathogen that managed to break through the epithelial barrier or peyer's pathes and comes into direct contact with macrophages. That could be MAP or AIEC or any other number of intracellular pathogens, but not the gut flora. I doubt the gut flora theory very strongly.
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