Crohn's Disease Forum » Diet, Fitness, and Supplements » SCD and Paleo Diets » Lack of Mucosal Healing From Modified Specific Carbohydrate Diet in Pediatric Patients With Crohn's Disease


10-08-2017, 08:56 AM   #1
eleanor_rigby
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Join Date: Aug 2012
Location: Cheshire, England, United Kingdom

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Lack of Mucosal Healing From Modified Specific Carbohydrate Diet in Pediatric Patients With Crohn's Disease

http://journals.lww.com/jpgn/Abstrac...ecific.10.aspx
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History:
2nd Generation affected

Symptoms since 08/2006 (age 17)

Emergency open bowel resection after perforation in 12/2011 (age 22) (wrongly diagnosed as burst appendix ). Three years remission following this unmonitored

Diagnosis:
Perforating small bowel Crohn's Disease 01/2016 (terminal ileum, duodenum)
Coeliac disease (age 26)

Meds:
50mg azathioprine (down from 75mg after my WBC dropped)
Gluten-free diet
10-12-2017, 08:37 PM   #2
wildbill_52280
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Join Date: Sep 2009
Just because clinical activity and biological parameters liek crp decline, doesn't mean youll get much mucosal healing.

Stepwise linear regression identified C reactive protein as predictive of the clinical index, and, successively, alpha 2-globulin, erythrocyte sedimentation rate, faecal alpha 1-antitrypsin, serum orosomucoid, and alpha 1-antitrypsin as predictive of the endoscopic index. Both predictions were poor--the biological variables accounting for only 22 and 44% respectively of the clinical and endoscopic index variations. In conclusion, Crohn's disease clinical activity seems to be virtually independent of the severity of the mucosal lesions and biological activity.
This has been known since 1994 I just came across this study a few weeks ago. https://www.ncbi.nlm.nih.gov/pubmed/7508411/
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Last edited by wildbill_52280; 10-12-2017 at 10:08 PM.
03-26-2018, 11:25 PM   #3
pathfnd1
 
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Join Date: Nov 2017
Location: vancouver, Washington
How do we know that there are no articles later than this 1994 article that contradict it?
Reply

Crohn's Disease Forum » Diet, Fitness, and Supplements » SCD and Paleo Diets » Lack of Mucosal Healing From Modified Specific Carbohydrate Diet in Pediatric Patients With Crohn's Disease
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