Crohn's Disease Forum » Books, Multimedia, Research & News » IBD Doubles Risk of Heart Attack...


03-21-2018, 10:13 AM   #1
Scipio
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IBD Doubles Risk of Heart Attack...

https://www.tctmd.com/news/inflammat...y-young-people

...compared to controls without IBD. However, it was impossible to determine whether the risk is associated with the drugs used to treat IBD or with the disease itself since they almost always occur together.
03-21-2018, 10:53 AM   #2
ronroush7
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Thanks
03-21-2018, 04:55 PM   #3
D Bergy
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I would speculate that any disease with a similar degree of inflammation would increase the likelihood of a heart attack.

Arteries get blocked largely as a result of inflammation and the bodies attempt to protect the arteries by forming plaque.

Dan
03-23-2018, 09:48 PM   #4
Lady Organic
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My blood platelets get high when I am in a flare. Thats actually the first maker of inflammation we can see in my reports.

We must watch out for signs of thrombosis (i.e leg swelling):

https://www.ncbi.nlm.nih.gov/pubmed/26270113

Hypercoagulability and Platelet Abnormalities in Inflammatory Bowel Disease.
Senchenkova E1, Seifert H1, Granger DN1.


Author information

1Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana.

Abstract

Patients with inflammatory bowel disease (IBD) exhibit a threefold higher risk for development of systemic thrombosis than the general population. Although the underlying causes of the increased risk for thrombus development remain poorly understood, there is a large body of evidence suggesting that abnormalities in coagulation, fibrinolysis, and platelet function may contribute to this response. Changes in hemostatic biomarkers are consistent with subclinical activation of coagulation system, including tissue factor activation, impaired protein C pathway, enhanced thrombin generation, and diminished fibrinolytic capacity. There is also evidence for an increased production and reactivity of platelets, with an enhanced formation of platelet-platelet and platelet-leukocyte aggregates. The altered coagulation and platelet function, and the predisposition to thrombus formation have also been demonstrated in animal models of IBD. The animal studies have revealed a major role for inflammatory cytokines, including tumor necrosis factor-α, interleukin (IL)-1β, and IL-6, as mediators of the platelet abnormalities and enhanced thrombus development in experimental IBD. These findings in animal models raise hope for the development of novel therapeutic strategies to reduce thrombosis-related mortality in IBD patients.
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''UC-like Crohn's'' (2001)
wrists + ankles arthropathies (2013)
on: 50mg 6-MP (Purinethol)+ B12 shots


Diet: ''IBD-AID'' : http://www.nutritionj.com/content/13/1/5+ organic food only
suppl Curcuminoid extract, Inulin,psyllium, apple pectin, Vitamin D

past meds:
pred 50mg, 5-ASA (pill, rectal), cortifoam, Imuran, Purinethol, methotrexate.

Last edited by Lady Organic; 03-24-2018 at 01:28 PM.
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