Crohn's Disease Forum » Books, Multimedia, Research & News » The effect of vitamin D on intestinal inflammation and faecal microbiota in patients with ulcerative colitis.


06-03-2018, 06:51 PM   #1
Lady Organic
Forum Monitor
 
Lady Organic's Avatar
The effect of vitamin D on intestinal inflammation and faecal microbiota in patients with ulcerative colitis.

''The effect of vitamin D on intestinal inflammation and faecal microbiota in patients with ulcerative colitis.''

https://www.ncbi.nlm.nih.gov/pubmed/29726893

Abstract

Background and Aims:

There is evidence vitamin D may be immunomodulatory and alter faecal microbiota, but results from clinical studies in humans to date have been inconclusive. This study aimed to assess the effect of vitamin D replacement in vitamin D deficient patients with and without ulcerative colitis (UC) on inflammation and faecal microbiota.

Methods:

Vitamin D was replaced over 8 weeks in patients with active UC (defined by faecal calprotectin ≥100 g/g), inactive UC (faecal calprotectin <100 g/g), and non-IBD controls with baseline 25(OH) vitamin D <50 nmol/L, and markers of inflammation and faecal microbiota analysed.

Results:

Eight patients with active UC, 9 with inactive UC and 8 non-IBD controls received 40,000 units cholecalciferol weekly for 8 weeks. Mean baseline 25(OH) vitamin D increased from 34 (range 12-49) nmol/L to 111 (71-158) nmol/L (p <0.001), with no difference across the groups (p = 0.32). In patients with active UC, faecal calprotectin levels reduced from median 275 to 111g/g (p = 0.02), platelet count reduced (mean 375 to 313x10 9/L, p = 0.03), and albumin increased (mean 43 to 45g/L, p = 0.04). These parameters did not change in patients with inactive UC or non-IBD controls. No changes in overall faecal bacterial diversity were noted although a significant increase in Enterobacteriaceae abundance was observed in patients with UC (p = 0.03).


Conclusions:

Vitamin D supplementation was associated with reduced intestinal inflammation in patients with active UC, with a concomitant increase in Enterobacteriaceae but no change in overall faecal microbial diversity.
__________________
''UC-like Crohn's'' since 2001:
on: 25mg 6-MP (purinethol)+ B12 shots
minor hands/wrists chronic arthritis since 01/2013

Diet: ''IBD-AID'' : http://www.nutritionj.com/content/13/1/5+ organic food only
suppl Curcuminoid extract, Inulin,psyllium, apple pectin, Vitamin D

past meds:
pred 50mg, 5-ASA, cortifoam, Imuran (failed) Purinethol (success) methotrexate (failed CD and arthritis).
06-04-2018, 05:52 PM   #2
wildbill_52280
Senior Member
 
Join Date: Sep 2009
more studies.
https://www.ncbi.nlm.nih.gov/pubmed/23594800
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991203/
__________________
Learn How Fecal transplants restore good bacteria that regulate inflammation to induce remission and how it has potential to be a cure for IBD in the future. Follow the link below.
http://www.crohnsforum.com/showthread.php?t=52400
Reply

Crohn's Disease Forum » Books, Multimedia, Research & News » The effect of vitamin D on intestinal inflammation and faecal microbiota in patients with ulcerative colitis.
Thread Tools


All times are GMT -5. The time now is 03:08 PM.
Copyright 2006-2017 Crohnsforum.com