Crohn's Disease Forum » Treatment » Imuran/Azathioprine/6-MP » Could azathioprine be insufficient for some Crohn's patients?


04-19-2018, 11:57 AM   #1
December's flower
 
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Could azathioprine be insufficient for some Crohn's patients?

Just wondering !
04-19-2018, 12:05 PM   #2
ronroush7
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Everyone is different. They might not respond in the same way. They may need something stronger.
04-19-2018, 12:28 PM   #3
December's flower
 
Join Date: Mar 2018
I've been on aza for approximately 18 months.
Last December my doctor told me that according to my weight I was undertreated.
So we agreed to increase the daily dose from 3 to 4 pills a day.
Indeed during the colonoscopy he detected 8 apthus ulcers near the anastomosis.
At that time all of my lab tests were perfect.
He also succesfully performed a balloon dilation cause the anastomosis was found to be strictured.
I have already booked an appointment with him for a second colonoscopy by June.
So if aza fails , are there enough biologics to match every single patient and put him in the desirable remission ? 😱
04-19-2018, 12:40 PM   #4
MarkStrobel33
 
Join Date: Jul 2017
Location: Surprise, Arizona
Just wondering !
This medication messed up my kidneys.
04-19-2018, 12:51 PM   #5
December's flower
 
Join Date: Mar 2018
Oh I'm so sorry how did you deal with this ?
04-19-2018, 12:59 PM   #6
ronroush7
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I've been on aza for approximately 18 months.
Last December my doctor told me that according to my weight I was undertreated.
So we agreed to increase the daily dose from 3 to 4 pills a day.
Indeed during the colonoscopy he detected 8 apthus ulcers near the anastomosis.
At that time all of my lab tests were perfect.
He also succesfully performed a balloon dilation cause the anastomosis was found to be strictured.
I have already booked an appointment with him for a second colonoscopy by June.
So if aza fails , are there enough biologics to match every single patient and put him in the desirable remission ? 😱
The ones that I am aware of are Remicade, Stelara, Humira, Simponi and Entyvio. There is always research going on.
04-19-2018, 01:07 PM   #7
MarkStrobel33
 
Join Date: Jul 2017
Location: Surprise, Arizona
Oh I'm so sorry how did you deal with this ?
I began taking this medication in 2001 after I was diagnosed with Crohn's. At some point, my dosage was increased (I cannot remember the dosage). However, I was in private practice at the time and I was unable to secure good healthcare insurance due to my pre-existing medical condition (Crohn's). All I could afford was catastrophic insurance. Because of this, my GI was giving me this medication in samples and I wasn't able to maintain regular blood work tests to determine how this med was affecting me. As a result, I now have stage 3 kidney disease. It is stable as long as I stay away from meds that negatively affect the kidneys.

In 2009, I needed to have an ileostomy. In spite of that, the Crohn's returned. And now I am on Entyvio infusions. The good thing about Entyvio is that it doesn't affect the kidneys like the med in question.

So, as long as you are on this med, please make sure that you get regular blood tests to make sure it isn't negatively affecting your kidneys.
04-19-2018, 01:20 PM   #8
December's flower
 
Join Date: Mar 2018
Oh god I hope everything to be right for you from now on.
I get regular lab testing , every single month.
One good thing about the country I live, Greece, is that despite of all the socioeconomical problems, all patients,who can't afford to have an insurance have free pass to doctors , medications and hospitals with just their social security number.
It's so sad to hear that the lack of a good insurance can bring up such serious complications to a patient.
Wish you sincerely the best
04-19-2018, 01:24 PM   #9
Scipio
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The ones that I am aware of are Remicade, Stelara, Humira, Simponi and Entyvio. There is always research going on.
There is also Cimzia.

And to answer the OP's question: yes, it is certainly possible for azathioprine to be insufficient for any given patient. It's a pretty good medicine in general, but it doesn't work for everyone and some cannot tolerate the side effects.
04-19-2018, 01:24 PM   #10
MarkStrobel33
 
Join Date: Jul 2017
Location: Surprise, Arizona
Oh god I hope everything to be right for you from now on.
I get regular lab testing , every single month.
One good thing about the country I live, Greece, is that despite of all the socioeconomical problems, all patients,who can't afford to have an insurance have free pass to doctors , medications and hospitals with just their social security number.
It's so sad to hear that the lack of a good insurance can bring up such serious complications to a patient.
Wish you sincerely the best
Thanks. I live in the USA. You probably are aware of our health care crisis. It is ridiculous. I wish you the best as well.
04-30-2018, 03:44 PM   #11
eleanor_rigby
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Ahh thatís so scary what blood test looks at the kidneys?? I get monthly blood tests for: FBC, LFT and U+E. Would that pick up kidney problems?
__________________


History:
2nd Generation affected

Symptoms since 08/2006 (age 17)

Emergency open bowel resection after perforation in 12/2011 (age 22) (wrongly diagnosed as burst appendix ). Three years remission following this unmonitored

Diagnosis:
Perforating small bowel Crohn's Disease 01/2016 (terminal ileum, duodenum)
Coeliac disease (age 26)

Meds:
50mg azathioprine (down from 75mg after my WBC dropped)
Gluten-free diet
04-30-2018, 04:00 PM   #12
MarkStrobel33
 
Join Date: Jul 2017
Location: Surprise, Arizona
Ahh thatís so scary what blood test looks at the kidneys?? I get monthly blood tests for: FBC, LFT and U+E. Would that pick up kidney problems?
I think that a routine blood work checks the condition of the kidneys. You might want to ask your doctor just to be sure.
04-30-2018, 06:56 PM   #13
Scipio
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Ahh thatís so scary what blood test looks at the kidneys?? I get monthly blood tests for: FBC, LFT and U+E. Would that pick up kidney problems?
Yes, U+E (urea plus electrolyte) test is an assessment of kidney function. Other common routine blood tests for kidney function include creatinine and EGFR.

EFGR is a calculated value based on your blood creatinine combined with your age and sex.
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Crohn's Disease Forum » Treatment » Imuran/Azathioprine/6-MP » Could azathioprine be insufficient for some Crohn's patients?
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