Crohn's Disease Forum » Treatment » Methotrexate » Methotrexate and leg pains

11-27-2010, 04:46 PM   #1
Join Date: Jul 2010
methotrexate and leg pains

Hello. My five year old son had his first methotrexate injection on Friday. All seemed fine, until the second night, when he woke up twice with extreme pain in his foot. Lasted 30 mins and had him screaming. Some kind of muscle or nerve pain?? (Hard to interpret from a 5 year old). Anyone else experience anything like this related to methotrexate? Any advice, remedies much appreciated. Thanks.
11-27-2010, 05:05 PM   #2
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Mountaingem's Avatar
Join Date: Jan 2010
Location: California

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Poor little guy! Has he been on pred? These meds often deplete the body of potassium and calcium, which causes muscle cramps,leg cramps, Charlie Horses, foot cramps. Try giving him some yogurt if he can tolerate dairy that's high in potassium and calcium for a few days. Also orange juice if he can tolerate it is high in potassium.

If he keeps having trouble, a blood test checking his vitamins/minerals/electrolytes might give you some answers.

Hope he feels better soon! Keep us posted!


Current Meds: Cimzia, Methotrexate, Prevacid, Sertraline, Nortryptaline, Prednisone, Atenelol
11-27-2010, 05:13 PM   #3
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Join Date: May 2010
Location: Kentucky

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Hey G, wish I could help. I was just reading some info on metho and couldn't find any sides mentioned that would seem to match especially since they use such a low dose to treat crohns. Has the GI been informed? What do they think? I hope it's just a passing thing and poor Ranger can get a long remission!! Good luck to you both!!
Mark, father of EJ

EJ dx w/ Crohn's 12/09
PSC 3/10

No more 6mp
Currently in the Humira Club
11-27-2010, 05:28 PM   #4
Join Date: Jul 2010
Hi Mark. I have emailed Ranger's doctor - he's usually pretty good at getting back to us - but it is the weekend here unfortunately. I did find some info online about leg cramps experienced by people taking Metho for arthritis - but since the dose and delivery is probably different it's hard to judge. Couldn't find anything related to Crohn's.
I hope it's not related - because otherwise the injection was very successful. Didn't even hurt.

Crohn's Disease Forum » Treatment » Methotrexate » Methotrexate and leg pains
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