Crohn's Disease Forum » Treatment » Imuran/Azathioprine/6-MP » What time of day do you take your Imuran?

12-21-2012, 02:30 PM   #1
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What time of day do you take your Imuran?

I'm wondering if its ok to take Imuran in the evening before bed, instead of the morning ?
My daughter just started Imuran a few days ago, 125 mg, and it has worsened her fatigue.
If you take it at night does it lesson it's effectiveness?
She's exhausted within an hour of taking it in the morning
Mom to Gab (20)
DX: Crohn's 2/2010
and Austin (18)
DX: Crohn's 7/2013
12-21-2012, 02:57 PM   #2
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Hey T...

Loads of folk on here take it at supper/bedtime because of the side effects, I think most do it because of the nausea it can cause. They say the side effects generally subside after about 3 weeks.

Dusty. xxx
Mum of 2 kids with Crohn's.
12-21-2012, 03:02 PM   #3
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My thinking is that as it takes a few weeks to get up to strength, i doubt it makes much difference what time you take it. Just remember you should take it with food (or soon after) as it can make you nauseous. Its not a good idea to eat too soon before bed either as it can lay in your stoamch and cause gas / cramping (as ive found)

Personally I take mine whenever I remember. Try to ain for dinner but sometimes just before bed
Current Meds:
2x 1200mg Mezavant, 3x50mg Azathioprine, Infliximab (6 weekly)
12-21-2012, 06:59 PM   #4
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I take 75mg at breakfast and 75mg at suppertime

Diagnosed since 1990
Current Medications: None currently. Was on Imuran (150mg/day) and 5-ASA (3000 mg/day) as maintenance meds prior to surgery
Surgeries: Left hemicolectomy 2014.
12-21-2012, 11:57 PM   #5
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I've been on it for 8 years. I don't notice any effects from it myself. So, I take it usually before bed because I think of it then.

Make sure they check her levels occasionally (not just checking liver function). My dose has changed a few times because of it.
12-21-2012, 11:57 PM   #6
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I always took mine just before bed. I had too much trouble with nausea if I took it at any other time.
Diagnosed Crohn's in 2011 (age 11)
Surgery in 2011 (age 19), laparoscopic ileocecal resection

Current treatment: Pentasa
12-22-2012, 12:30 AM   #7
Crohn's Mom
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CrohniePilot ~ thank you ~ she will have her blood drawn every 2 weeks for the first 3 draws, and then once a month

I suggested to her to try taking it in the evening and see if that helps lessen the fatigue.
12-22-2012, 05:41 PM   #8
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sarah takes in the morning and seems to only have nausa if she doesnot eat enough before the car trip.

She exactly has it with second breakfast after swimming training
Mother of Sarah dx aged 16, Jan 2012
DX - CD 1/12, asthma
Small bowel to small bowel fistula

Meds: ), azathioprine 200mg, Mesalazine 1.2g x 2, seretide 250 x 2 (asthma), ventolin (as needed)

Currently no supplements.

Has previously taken Multi B, Caltrate, B12 & Iron

Prednisolone (from 30 mg 01/02/2012 to 17/06/2012, 30mg 24/10/12-28/12/12, 50mg 24/1/13-27/4/13)
01-27-2013, 10:06 AM   #9
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I'm on 150 mg and take it in the evening. I've been on it for several months and still can't take it in the morning due to nausea. The nausea isn't that bad but I'm highly sensitive to it and even slight nausea shuts me down. I try to take it with a meal but it it's late I'll just take it whether I've eaten recently or not. If I'm actively hungry I have a snack to take it with.
Crohn's of ileum dx'd 2008.
Imuran, 150 mg
01-27-2013, 10:24 AM   #10
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I was wary of getting nauseous when taking Imuran, so I never took it at any other time except before bed. Works fine - and I think I might be sleeping better, too!
Hi, I'm Emma!
19 years old.
Diagnosed: Crohn's disease, August 2007
Currently on: Humira 40mg fortnightly
01-27-2013, 10:25 AM   #11
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I take 75mg at breakfast and 75mg at suppertime
01-27-2013, 10:26 AM   #12
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I take mine before bed but I don't notice any side effects, I just take it then so I remember
Diagnosed with CD March 08 at 17
Currently on:


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01-27-2013, 08:34 PM   #13
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I just started taking 6MP last week and my dr has me only on 50mg in the morning. I feel like I'm more tired than usual midday but no nausea/vomiting. I wonder if that will occur if my dose is increased.
02-01-2013, 04:26 AM   #14
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I take 100 mg before bed as it makes me sleepy. I used to take it in the morning but felt do tired all day. Now I have more energy.
DX 1998
Meds: 2.5mg Plendil ER. Azathioprine 100mg; Inhibace+ 12.5mg; gastrosoothe 60mg; Simvastatin 40mg; Loratadine 20mg; Fluoxetine 40mg; Provera 10mg; Metformin 2.55g; Cal d forte; 1.25mg, Humira; Panadol 4g; Pred 3mg

Crohn's Disease Forum » Treatment » Imuran/Azathioprine/6-MP » What time of day do you take your Imuran?
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