My husbands GI doc put him on Imuran and it was a nightmare, after being on it for 3 weeks his Lipase levels skyrocketed and he got pancreatitus, and he felt like hell. He has Crohns and the doc thought it would be a good maintenance drug for him...NOT SO! So he has been off Imuran and ALL meds for about a month and is feeling better than he has in a long, long time. He is also on an anti inflammatory diet now, which I believe is helping him immensely!