My son has been on Methotrexate for about a year and a half now. He did really well on it for about a year but it has stopped working these past few months
So... maybe we'll be adding Remicade!
As far as side effects... he didn't really notice anything except for one week earlier on when he forgot to take enough folic acid - then he was a little nauseous and tired... never had that problem again. I think he lost a little hair in the first few months but then it seemed to grow back - no big deal.
He has taken it by injection and has learned to do it himself at home without problem.
It's too bad that it's stopped helping but it was great - it bought us a year or so worth of 'remission', I think!
And, I think there are quite a few kids on the forum who have had some success with that combo of MTX and Remicade.
I hope it works for your guy too!!