02-06-2013, 06:53 AM   #1
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bigtruck's Avatar
Join Date: Feb 2009
Location: United Kingdom
Mercaptopurine dosage

Hi all I've just been changed from aza to mercaptopurine and have been told to take 50mg daily for 2 weeks then increase to 100mg. What is the "normal" dose you peeps are taking? Has anyone any good or bad reports on it?
02-06-2013, 07:09 AM   #2
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Johnnysmom's Avatar
Join Date: Oct 2011
Location: Cincinnati, Ohio

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My son, who was 11 years old at the time was started on 50 mg. He went as high at 75mg and as low as 25mg over the next year. They added allopurinol at one point too. Last week his GI put him back at 50 mg a day after a year of adjusting. Basically, it takes a while to find the right dose for you. This will depend on your weight and metabolism. Our Dr. said if you are feeling side effects the dose is probably too high. Although there is an adjustment period at first when you might have some side effects. They will monitor your blood levels so you get a "therapeutic level". Not too high or too low. My son is now 5'9" and 126lbs.

Make sure to drink a full glass of water when taking it and keep hydrated. We were also told to avoid milk products 1 hour before. My son finds it easiest to take before bed.

It has been a wonderful medication for him. I hope you have the same experience.
Mom of Johnny
Dx Oct 11 2011 Crohns disease
Prednisone done 12/30/11
6mp 50mg every day
Allopurinol 50mg -discontinued per new G.I. on 11/01/12
Multi Vitamin
Vitamin D3 1000mg
02-06-2013, 07:10 AM   #3
nogutsnoglory's Avatar
Join Date: Sep 2009
Location: New York

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I have been on 50mg and 75mg of 6mp. I think the higher doses are more likely to be effective.
02-06-2013, 07:24 AM   #4
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Jer's Avatar
Join Date: Oct 2012
Location: CT

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Like Johnnysmom eluded to, there is blood work to see if you are getting a theraputic dose or not.

I was at 100mg per day and was bumped up to 125mg/day based on the results of that.
02-06-2013, 01:46 PM   #5
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Join Date: Jul 2012
Location: Barrington, New Jersey

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My 6mp dosage has been changed quite a bit, depending on my disease activity and my white blood count level. I am not alternating doses: 50 mg one day and then 75 mg the next.

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