Crohn's Disease Forum » Treatment » 5-ASA/Mesalamine » Pentasa granules?

03-14-2009, 08:24 PM   #1
New Member
Join Date: Jun 2008
Pentasa granules?

Does anyone know anything about Pentasa® granules? I'm currently taking 6 500 mg pills daily and I have been facing issues with these pills for some time. There is not supposed to be too side effects present with the pills, but it sounds like this grauule alternative could possibly solve my problems. With the pills I get bloated all the time which isn't my biggest problem with them. My main issue is the fact that I get light headed if I don't eat enough food at a certain time and then take the pills. I started researching alternatives and this Pentasa® granules sounds like it could do the trick. Only needs to be taken once daily at most twice.
03-15-2009, 05:01 PM   #2
Senior Member
AIjen's Avatar
Join Date: Nov 2008
Location: Wisconsin
Do they give just the granules? I'm on Pentasa as well, but inside the bright blue capsule are tons of little white granules.

The only side effect I had when taking it in the beginning is abdominal cramping. I don't know for sure that it was the Pentasa though, so it was just a thought. No light-headedness with it.

Good luck!
Current Diagnoses: Asthma (Can't remember), Hashimoto's (June 07), Psoriasis (March 08), Undifferentiated Connective Tissue Disease (Jan. 08), Fibromyalgia (Jan. 08), Crohn's (Dec. 08), Chronic Fatigue Syndrome (June 12)

Current Medications: Levothyroxin, Lyrica, Advair, Cimzia, Zyrtec, and Prevacid. Back on Pentassa 12/04/12.
03-17-2009, 06:28 PM   #3
Join Date: Aug 2008
Location: New Jersey
My son takes the same amount 2 500mg 3xs a day they are blue and have little granules inside. If he happens to throw up, which he does frequently, you can see the little granules. So, if you are taking the HUGE blue pill then you already are taking the granules.
03-18-2009, 12:21 PM   #4
Senior Member
danman's Avatar
Join Date: Sep 2008
I get mine in a sachet.

I pour them onto my tongue and drink them down.
03-21-2010, 05:42 PM   #5
scorned angel
New Member
Join Date: Mar 2010
Location: gravesend, kent, United Kingdom
Hi, i know this thread is quite old but i was on pentasa tablets for a few months and had terrible cramps, bloating & light headedness plus they are really difficult to swallow. Switched to granules about 3 months ago and its MUCH better, easier to take, only have to take 2 sachets a day and ive had ZERO side effects with it.
hope this helps someone
L x
03-21-2010, 08:05 PM   #6
David in Seattle
Senior Member
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Join Date: Feb 2010
The granules are all enteric coated to produce a prolonged release throughout the intestines once they enter the small bowel. I tried Pentasa in the form of capsules very briefly, gave me a huge headache & ringing in the ears, the latter effect being a classic salicylate side effect. Seems odd that simple eliminating the gelatin cap would eliminate side effects, but who knows?
03-22-2010, 01:19 PM   #7
Astra's Avatar
Join Date: Jan 2010
Location: St Helens, Merseyside, United Kingdom

My Support Groups:
My Pentasa aren't in a capsule, they're in a tablet, but they go granular when wet


Dx Crohn's in TI 2005 symptoms for 15 years prior

BEEN ON -Azathioprine, 6MP, Prednisolone, Pentasa, Budesonide, Metronidazole, Humira, Methotrexate,

NOW ON -Amitriptyline 25mg
21/02/14 Right hemicolectomy surgery!/profile.p...4208290&ref=ts

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