Crohn's Disease Forum » Treatment » Imuran/Azathioprine/6-MP » Azathioprine and Allopurinol

09-06-2013, 09:14 PM   #1
AussieChick's Avatar
Join Date: Apr 2013
Location: South Australia, Australia

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Azathioprine and Allopurinol

Ok so I have been on Azathioprine (Imuran) for about 4 months now and been on 150mg. My ibd nurse has just emailed me and said they have my blood results back and that I break down Azathioprine in such a way that I will benefit from a reduction in Azathioprine to 50 mg daily and addition of Allopurinol 100mg daily. There are 2 pathways in which this drug is metabolised (broken down) in the body, one is useful and the other is not, and adding in allopurinol whilst reducing the Azathioprine results in more of the drug going down the useful pathway, and prevents liver damage.

Has this happen to anyone else and does the allopurinol have any side effects etc ?


Crohn's you're an ASS!!!
Current Meds
Imuran 50mg
Allopurinol 100mg

Past Meds
Pentasa 3g (Didn't work)
Was on Imuran 150mg
Finally off Pred wooo

09-09-2013, 12:38 AM   #2
Catherine's Avatar
Join Date: Jan 2012
Location: Melbourne, Victoria, Australia

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My daughter has got that far yet.

The aim is to use a side effect of allopurinol to increase the 6TGN levels, and decrease the 6MMP levels
Mother of Sarah dx aged 16, Jan 2012
DX - CD 1/12, asthma
Small bowel to small bowel fistula

Meds: ), azathioprine 200mg, Mesalazine 1.2g x 2, seretide 250 x 2 (asthma), ventolin (as needed)

Currently no supplements.

Has previously taken Multi B, Caltrate, B12 & Iron

Prednisolone (from 30 mg 01/02/2012 to 17/06/2012, 30mg 24/10/12-28/12/12, 50mg 24/1/13-27/4/13)
09-09-2013, 10:21 AM   #3
Senior Member
Patricia56's Avatar
Join Date: Jul 2012
Location: Northern California, USA
Can't say personally but a number of kids require this to avoid elevated liver enzymes. I've never heard of problems with side effects from the allopurinol.
Badger, 18, CD, overall great guy
Dxd age 10, 2006 after nearly 1 year of active sx
Current CD meds: Remicade, Methotrexate and Omeprazole, Vit. D, Calcium, Folic Acid, Probiotic

Nothing I say here should be construed as medical advice. I am not a doctor. These are just my opinions.
09-14-2013, 11:22 PM   #4
Jennifer's Avatar
I haven't had to do that myself with 6MP but the forum wiki on Allopurinol pretty much sums it up and also mentions the possible side effects. Sorry I'm not much more help than that. I hope you do well on this new treatment plan. Keep us posted AussieChick. *HUGS*
Diagnosis: Crohn's in 1991 at age 9
Surgeries: 1 Small Bowel Resection in 1999; Central IV in 1991-92
Meds for CD: 6MP 75mg
Things I take: Tenormin 25mg (PVCs and Tachycardia), Junel (endometriosis), Tylenol 3 (Osteoarthritis), Zantac 150mg 2/day (acid reflux), Klonopin 1mg (Panic Disorder), Imitrex 25mg (migraines), Zofran 8mg (nausea)
Currently in: REMISSION Thought it was a flare but it's just scar tissue from my resection. Dealing with a stricture. Remission from my resection, 19 years and counting.
09-15-2013, 03:00 AM   #5
AussieChick's Avatar
Join Date: Apr 2013
Location: South Australia, Australia

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thanks so much everyone will let you know how I go, been on it on 5 days now, so far no side effects.
09-17-2013, 10:55 AM   #6
Jmrogers4's Avatar
My son was on the combo for about a year and a half. Never had any side effects and finally saw some relief from symptoms. Hope it works well for you.

Mom to Jack (18) dx Crohn's 2/2010
Remicade - started 1/9/14; 7.5ml/kg every 6 weeks
Past meds: Imuran/Azathioprine; allopurinol; methotrexate; LDN; Prednisone; Apriso; Pentasa; EEN

Husband dx Crohn's 3/1993
currently none due to liver issues

Crohn's Disease Forum » Treatment » Imuran/Azathioprine/6-MP » Azathioprine and Allopurinol
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