Crohn's Disease Forum » Books, Multimedia, Research & News » Gut Bacteria May Play Role in Crohn’s Disease

03-12-2014, 03:51 PM   #1
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Gut Bacteria May Play Role in Crohn’s Disease
03-12-2014, 06:14 PM   #2
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Here is the whole paper,dam good.
I still think there is a mucosal breach, the immune system kills off everything
it can,then the rest become more pathogenic.
Old Mike
03-12-2014, 06:38 PM   #3
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here is the actual study for more details.

what was surprising is that this study found a greater lack of bifidobacteria in patients then previous studies, which tended to find reduced diversity in clostridia, which make up 75% of the firmicutes, which which make up the majority of bacteria that dominate mucosal surface. they still found a lack of diversity in the clostridia tho, so previous studies are liekly to be correct.

I'm so glad this was a very large study, now it will be hard to doubt the role of bacteria in IBD. It is now ever more likely a fecal transplant could restore the loss in diversity among the benefical microbes that are missing in IBD patients.

for some info on fecal transplants see this thread-
03-12-2014, 07:00 PM   #4
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There's still a lot of research to be done. Characterizing the gut flora is one thing; understanding the cascade and development of the disease is still ongoing.
03-13-2014, 05:57 AM   #5
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And here's the same report from Science Daily. Interesting.
04-01-2014, 08:07 PM   #6
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Very interesting article. Thanks for sharing this!
08-30-2014, 12:51 PM   #7
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And another recent article along these lines.
08-30-2014, 11:43 PM   #8
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Oh great they revealed which pathogens...NOT! MAP and Evasive E.Coli? Hopefully I won't have to care about this shit with the SSI. Sorry peeps, but things aren't moving fast enough for all the poor people suffering.

Its all about the profit!

Last edited by sir.clausin; 08-31-2014 at 12:12 PM. Reason: add info point
08-31-2014, 04:25 AM   #9
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there's two camps and two explanations for CD that developed over the years

-CD is caused by dysbiosis:

arguments for:

-dysbiosis can be seen
-it happens in areas where the microbiome is, ileum and colon
-people who have had antibiotics seem more susceptible to getting CD

arguments against:

-inducing colitis in mice is not relevant to the CD model in humans, it discredits a lot of microbiome studies
-the most accurate CD model is a mouse infected with an AIEC strain, not dysbiosis, however dysbiosis might enable AIEC to proliferate
-UC and CD are clinically very different diseases
-many intestinal diseases have dysbiosis, but none of them are caused by dysbiosis
-there is no consistency in the type of dysbiosis, some studies show F Prau is underrepresented, some show it is overrepresented
-the ileum is involved not because of the microbiome, but because of the peyer's patches there
-NOD2 / ATG16L1 / IL23 variants result in macrophage deficiencies, not related to the microbiome
-if only the microbiome was involved, you wouldn't expect to see transmural inflammation, nor should you see fistulas, you do in CD
-the inflammation is patchy
-fecal transplants don't seem to have a high success rate

There's also many people who are in between those arguments, AIEC is an intracellular pathogen, but you can make the crazy argument that it is part of the micriobiome, since it attaches to epithelial cells and can be found in the lumen, but most people know it is an intracellular pathogen. Just because a bacteria is found in the intestine doesn't mean you can say the cause is dysbiosis, no one says intestinal TB is caused by dysbiosis, even though there is often dysbiosis in intestinal TB, and dysbiosis makes you more susceptible to infections. Maybe some get more funding if they dress up infections as "bad and good bacteria", I don't know.

Last edited by kiny; 08-31-2014 at 04:51 AM.

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