So, I started having cramps earlier in the week, Wednesday night went to emerg, just to make sure nothing too bad was going on. Just a minor flare. I'm on prednisone for a few weeks. How long does it take to kick in? My knees are feeling a little swollen aswell. This usually happens to me in a flare, but it's been awhile since I've taken prednisone. Right now I'm on 35 mg? I think it's 7 pills, tapering off one pill per week.