Don't worry/concentrate on the side effects. we could all give you our side effects but no one patient is the same as the next. I had depression with Humira but have not found one other person that has had this.
Remicade infusions were a Godsend. I got a slight, 2-day, depression after my first Remicade infusion - then never again.
Humira did not work on my fistulas but it seemed to keep my extra-intestinal manifestations under control.
I'm taking a break from biologics, after being on them for 14 years. I've been off since February and I may ask for a med change before going back on it (I've also been on ONLY Asacol since 1999).