08-19-2014, 12:09 PM   #1
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Maya142's Avatar
False Negative?

A friend's 12 year old son is being worked up for IBD. He has diarrhea that wakes him up at night and sometimes has blood in it. Plus, his father has Crohn's. They just did Fecal Calprotectin and it came back very low: <15.6. She was asking if it's possible it was a false negative (and I had no idea). Does anyone know?

I know his ESR and CRP are not elevated, but neither are his father's.
Mom of M (20)
diagnosed with Crohn's Disease at 16
Juvenile Idiopathic Arthritis at 12
Juvenile Ankylosing Spondylitis at 16

Mom of S (23)
dx with JIA at 14
Ankylosing Spondylitis at 18
08-19-2014, 12:24 PM   #2
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Farmwife's Avatar
Join Date: Apr 2012
Location: Michigan

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grace is the same way. Just now after 3 years is her sed rate starting to elevated. her FC as been between 12-70 but never higher.
The GI said early IBD is a lot more difficult to count on numbers.
I'm mom to............... Little Farm Girl 9 yr old
Ibd (microscopic)
dx Juvenile Arthritis
dx Erthema Nodosum
Bladder and Bowel Dysfunction
Ehlers-Danlos Syndrome dx (1/26/17)
Remicade started on (9/8/14)Every 2 wks
MTX started AGAIN on 11/21/17
EN/EEN- since (1/12/13)
Past Meds- LDN, Humira, Pred, MTX, Sulfasalazine,
08-19-2014, 12:28 PM   #3
Senior Member
Join Date: May 2014
I read about both false negatives and false positives (as in not due to IBD or active infection but elevated) when researching. I will try to find a good study. Basically, the end results was if you tested X number of people by fecal calprotectin to determine if scope needed, you will end up scoping a few who won't have IBD if you only scoped the elevated numbers but you would also miss a small number of people with IBD who didn't get scoped due to low numbers. It's a good test, but it's not diagnostic. I would have been thrilled to have a normal fecal calprotectin for my son. But I would not have ended the IBD work up there.
08-19-2014, 12:40 PM   #4
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Maya142's Avatar
Yes, M's FC also runs low - we've had as low as 26 (or was it 36?) and as high as 400+ but compared to many of the other kids here, that's not even very high. She was also diagnosed with "early Crohn's". M also has very low inflammatory markers (ESR is usually between 1-4).
08-19-2014, 05:27 PM   #5
Catherine's Avatar
Join Date: Jan 2012
Location: Melbourne, Victoria, Australia

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Small bowel crohn's is also know for having a lower fc.
Mother of Sarah dx aged 16, Jan 2012
DX - CD 1/12, asthma
Small bowel to small bowel fistula

Meds: ), azathioprine 200mg, Mesalazine 1.2g x 2, seretide 250 x 2 (asthma), ventolin (as needed)

Currently no supplements.

Has previously taken Multi B, Caltrate, B12 & Iron

Prednisolone (from 30 mg 01/02/2012 to 17/06/2012, 30mg 24/10/12-28/12/12, 50mg 24/1/13-27/4/13)

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