Crohn's Disease Forum » Books, Multimedia, Research & News » Research into MAP as the cause of Crohn's


 
11-12-2016, 06:51 PM   #181
Scared1
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New article: Concurrent Resolution of Chronic Diarrhea Likely Due to Crohn's Disease and Infection with Mycobacterium avium paratuberculosis.

https://www.ncbi.nlm.nih.gov/pubmed/27833911

Abstract
Examination of samples of stool from a 61-year-old male patient, presenting with the clinical symptoms of Crohn's disease (CD), revealed massive shedding of acid fast bacilli with the morphology of Mycobacterium avium paratuberculosis (MAP), the causative agent of Johne's disease in cattle. MAP was cultured from the stool. Biotyping of the bacterium isolated from cultures of stool demonstrated, it was the Indian Bison biotype of MAP, the dominant biotype infecting livestock and humans in India. Based on this finding and because the patient was unresponsive to standard therapy used in India to treat patients with gastrointestinal inflammatory disorders, the patient was placed on a regimen of multi-antibiotic therapy, currently used to treat tuberculosis and CD. After 1 year of treatment, the patient's health was restored, concurrent with cessation of shedding of MAP in his stool. This patient is the first case shown to shed MAP from the stool who was cured of infection with antibiotics and who was concurrently cured of clinical signs of CD.
KEYWORDS:
Crohn’s disease; ELISA; IS900 PCR and IS1311 PCR_RE; Mycobacterium avium paratuberculosis; antibiotic therapy; stool culture and microscopy for MAP
11-12-2016, 06:52 PM   #182
Scared1
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Join Date: Apr 2016
AIEC is probably the other culprit imo, lots of literature stacking up suggesting so, also seems to be a few therapies targeting AIEC in the works... hopefully between the map vaccine and qu biologic's ssi vaccine we can say goodbye to this horrible condition.
Amen to that.
11-13-2016, 11:12 PM   #183
irishgal
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Prof. Thomas Borody's latest research from October 2016. He did a small study of AMAT in 8 treatment naive patients. All went into remission between 4-21 weeks. Also, the patients experienced deep mucosal healing. Full ACG poster link and his intro below:

http://thecrohnsinfection.org/prof-t...aive-patients/
__________________
Currently on: Anti-MAP therapy and loving life! Full remission since Jan 2015. Clarithromycin, rifampin and low dose naltrexone. (Levofloxicin had too many side effects so discontinued after 5 months.) Resources on human MAP and Crohn's here: HumanPara.org.

Past (failed) Treatments: Remicade, Humira, Prednisone, Pentasa, Azulfadine, Lialda, No gluten/dairy/sugar/coffee or processed food in general. Flagyl worked but not long term.
11-27-2016, 03:52 PM   #184
eleanor_rigby
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This is interesting regarding bacteria: http://www.cbc.ca/beta/news/canada/o...tudy-1.3864650
12-13-2016, 09:46 AM   #185
Scared1
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Join Date: Apr 2016
Fingers crossed!

"RedHill's late-stage study of RHB-104 in Crohn's to continue as planned
Dec. 13, 2016 9:21 AM ET|By: Douglas W. House, SA News Editor
Following a pre-planned review, the independent Data and Safety Monitoring Board (DSMB) unanimously recommends that RedHill Biopharma's (NASDAQ:RDHL) Phase 3 clinical trial, MAP US, assessing combination antibiotic RHB-104 for the treatment of Crohn's disease continue as planned without modification. Two additional independent DSMB reviews will take place after 50% and 75% of subjects have completed 26 weeks in the study. The next review should happen in Q2 2017.
According to ClinicalTrials.gov, the estimated final data collection date for the primary endpoint, remission at week 26, is September 2017. The estimated study completion date is April 2018."
10-05-2017, 03:28 AM   #186
eleanor_rigby
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Redhill results expected early:

https://www.healio.com/gastroenterol...expected-early
01-31-2018, 08:35 PM   #187
Crohn2357
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MAP and RA - Study
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