Crohn's Disease Forum » Treatment » Imuran/Azathioprine/6-MP » When does fatigue recede, if ever from IMURAN?

11-20-2014, 01:22 PM   #1
fewdalord's Avatar
Join Date: Oct 2014
Location: North Carolina

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When does fatigue recede, if ever from IMURAN?

I just started 150 mg each day. Feel horribly fatigued. I expected this because I've taken it before but can't remember when it recedes. My vague recollection is that it goes away to some extent but back when I took it I was taking wellbutrin which is very energizing so I'm not sure if the fatigue ever went away. Your thoughts? BTW I take it at bedtime.
11-22-2014, 08:00 PM   #2
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Location: Ontario

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Sorry I missed your post.

From my recollection it took quite awhile. I started taking it before bed because it made me so tired.
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11-23-2014, 09:31 AM   #3
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I was on 6mp and was always weak and sick. Everyone is different. It may take time to adjust or maybe lowering the dose will help.
12-03-2014, 04:57 PM   #4
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Location: Bloomington, Indiana

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I agree with nogutsnoglory. Currently being on Remicade (last infusion Dec 1), Imuran and Prednisone - and Cymbalta and Lyrica to counteract the stupid neurapathy, one minute I have boundless energy, the next I'm more than half passed out on my desk.

Everyone reacts to things differently, and then you start combining all this stuff and who knows......
DX Crohn's 1971
Crohn's Surgeries 1971, 1974, 1984x2, 1993, 2007,2016
11 Kidney Stones from 1996 due to resections
All the standard drugs/advice from the 70's 80's 90s
Now: Lyrica & Cymbalta (Neuropathy)
Fish Oil, B12 injection monthly
Dec 21 2011 started Remicade
February 2012 off of Pentase!
Nov 2014 Back on Imuran
Jan 2015 off Remicade
Mar 2015 on Humira
June 2016 on cimzia
Dx short Bowel July 2017
12-05-2014, 11:20 PM   #5
CrohnsLifer's Avatar
Join Date: Nov 2014
Location: Mississauga, Ontario
I'm on 250 mg of Azathioprine daily and I sleep the night and half the day away, the consolation is that it's not a steroid.

The other thing I've noticed that is rarely mentioned is that I'm constantly jittery and out of sorts mentally.
12-10-2014, 04:24 PM   #6
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Join Date: Jan 2014
Location: Toronto, ON, Canada

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Imuran only left me with fatigue/brainfog for the first week or so. After that it seemed to clear up. 6mp I had no side-effects with.
Diagnosis: Fistulizing Crohn's, 2011 (originally Dx as Ulcerative Pancolitis)
Past Medication: Pentasa, Remicade, Prednisone, Imuran
Current Medication: Humira (biweekly), 100mg 6mp
Unrelated Medication: 36mg Concerta, 75mg Pregabalin
Currently: In remission!

Crohn's Disease Forum » Treatment » Imuran/Azathioprine/6-MP » When does fatigue recede, if ever from IMURAN?
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